M Bunemann
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Explore the profile of M Bunemann including associated specialties, affiliations and a list of published articles.
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34
Citations
792
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Recent Articles
1.
Mattern A, Machka F, Wickleder M, Ilyaskina O, Bunemann M, Diener M, et al.
Org Biomol Chem
. 2018 Sep;
16(36):6680-6687.
PMID: 30177977
Gold nanoparticles (NP) with a functionalized ligand shell offer the possibility to potentiate the action of agonists at the receptor site by multivalency. In order to find out whether this...
2.
Werthmann R, Lohse M, Bunemann M
J Physiol
. 2010 Nov;
589(Pt 1):181-93.
PMID: 21059757
The barrier function of the endothelium is controlled by the second messengers Ca2+ and cAMP that differentially regulate the permeability of endothelial cells. The Ca2+-elevating agent thrombin has been demonstrated...
3.
Werthmann R, von Hayn K, Nikolaev V, Lohse M, Bunemann M
J Physiol
. 2009 Jun;
587(Pt 16):4091-104.
PMID: 19546162
The crosstalk between Ca(2+) and cAMP signals plays a significant role for the regulation of the endothelial barrier function. The Ca(2+)-elevating agent thrombin was demonstrated to increase endothelial permeability and...
4.
Baumer Y, Spindler V, Werthmann R, Bunemann M, Waschke J
J Cell Physiol
. 2009 May;
220(3):716-26.
PMID: 19472214
Barrier stabilizing effects of cAMP as well as of the small GTPase Rac 1 are well established. Moreover, it is generally believed that permeability-increasing mediators such as thrombin disrupt endothelial...
5.
Lohse M, Hein P, Hoffmann C, Nikolaev V, Vilardaga J, Bunemann M
Br J Pharmacol
. 2008 Jan;
153 Suppl 1:S125-32.
PMID: 18193071
G-protein-coupled receptors (GPCRs) are the largest group of cell surface receptors. They are stimulated by a variety of stimuli and signal to different classes of effectors, including several types of...
6.
Hoffmann C, Zurn A, Bunemann M, Lohse M
Br J Pharmacol
. 2007 Dec;
153 Suppl 1:S358-66.
PMID: 18059316
The G-protein-coupled receptors (GPCRs) represent one the largest families of drug targets. Upon agonist binding a receptor undergoes conformational rearrangements that lead to a novel protein conformation which in turn...
7.
Krasel C, Vilardaga J, Bunemann M, Lohse M
Biochem Soc Trans
. 2004 Oct;
32(Pt 6):1029-31.
PMID: 15506955
The kinetics of G-protein-coupled receptor activation and deactivation has, so far, been measured only indirectly, most frequently by assessing the production of various second messengers. We have developed methods based...
8.
Bunemann M, Bucheler M, Philipp M, Lohse M, Hein L
J Biol Chem
. 2001 Oct;
276(50):47512-7.
PMID: 11591725
Although G protein-coupled receptor-mediated signaling is one of the best studied biological events, little is known about the kinetics of these processes in intact cells. Experiments with neurons from alpha(2A)-adrenergic...
9.
Bunemann M, Hosey M
Life Sci
. 2001 Jun;
68(22-23):2525-33.
PMID: 11392622
The M2 muscarinic acetylcholine receptor (mAChR) activates Gi protein coupled pathways, such as stimulation of G-protein activated inwardly rectifying K channels (GIRKs). Here we report a novel heterologous desensitization of...
10.
Roseberry A, Bunemann M, Elavunkal J, Hosey M
Mol Pharmacol
. 2001 Apr;
59(5):1256-68.
PMID: 11306711
The internalization of the M(2) muscarinic cholinergic receptor (mAChR) proceeds through an atypical pathway that is independent of arrestin and clathrin function and shows a unique sensitivity to dynamin when...