Lynn Loughlin
Overview
Explore the profile of Lynn Loughlin including associated specialties, affiliations and a list of published articles.
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16
Citations
739
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Recent Articles
1.
Dean A, Nilsen M, Loughlin L, Salt I, MacLean M
Hypertension
. 2016 Jun;
68(2):446-54.
PMID: 27296990
Females are more susceptible to pulmonary arterial hypertension than males, although the reasons remain unclear. The hypoglycemic drug, metformin, is reported to have multiple actions, including the inhibition of aromatase...
2.
Johansen A, Dean A, Morecroft I, Hood K, Nilsen M, Loughlin L, et al.
Pulm Circ
. 2016 May;
6(1):82-92.
PMID: 27162617
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT(+)) in mice...
3.
Wallace E, Morrell N, Yang X, Long L, Stevens H, Nilsen M, et al.
Am J Respir Crit Care Med
. 2015 Apr;
191(12):1432-42.
PMID: 25871906
Rationale: Females are predisposed to pulmonary arterial hypertension (PAH); evidence suggests that serotonin, mutations in the bone morphogenetic protein receptor (BMPR) II gene, and estrogens influence development of PAH. The...
4.
Wright A, Ewart M, Mair K, Nilsen M, Dempsie Y, Loughlin L, et al.
Cardiovasc Res
. 2015 Mar;
106(2):206-16.
PMID: 25765937
Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH. We have previously...
5.
Mair K, Wright A, Duggan N, Rowlands D, Hussey M, Roberts S, et al.
Am J Respir Crit Care Med
. 2014 Jun;
190(4):456-67.
PMID: 24956156
Rationale: The incidence of pulmonary arterial hypertension is greater in women, suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males, exogenously administered estrogen can protect against...
6.
Dempsie Y, MacRitchie N, White K, Morecroft I, Wright A, Nilsen M, et al.
Cardiovasc Res
. 2013 Mar;
99(1):24-34.
PMID: 23519266
Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic...
7.
White K, Johansen A, Nilsen M, Ciuclan L, Wallace E, Paton L, et al.
Circulation
. 2012 Aug;
126(9):1087-98.
PMID: 22859684
Background: Pulmonary arterial hypertension (PAH) is a hyperproliferative vascular disorder observed predominantly in women. Estrogen is a potent mitogen in human pulmonary artery smooth muscle cells and contributes to PAH...
8.
Morecroft I, White K, Caruso P, Nilsen M, Loughlin L, Alba R, et al.
Mol Ther
. 2012 Apr;
20(8):1516-28.
PMID: 22525513
Serotonin is produced by pulmonary arterial endothelial cells (PAEC) via tryptophan hydroxylase-1 (Tph1). Pathologically, serotonin acts on underlying pulmonary arterial cells, contributing to vascular remodeling associated with pulmonary arterial hypertension...
9.
Dempsie Y, Nilsen M, White K, Mair K, Loughlin L, Ambartsumian N, et al.
Respir Res
. 2011 Dec;
12:159.
PMID: 22185646
Background: Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1...
10.
White K, Loughlin L, Maqbool Z, Nilsen M, McClure J, Dempsie Y, et al.
Physiol Genomics
. 2011 Feb;
43(8):417-37.
PMID: 21303932
Pulmonary arterial hypertension (PAH) is up to threefold more prevalent in women than men. Female mice overexpressing the serotonin transporter (SERT; SERT+ mice) exhibit PAH and exaggerated hypoxia-induced PAH, whereas...