Lynn Loughlin
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Explore the profile of Lynn Loughlin including associated specialties, affiliations and a list of published articles.
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16
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739
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Recent Articles
11.
White K, Dempsie Y, Nilsen M, Wright A, Loughlin L, MacLean M
Cardiovasc Res
. 2010 Dec;
90(2):373-82.
PMID: 21177701
Aims: Idiopathic and familial forms of pulmonary arterial hypertension (PAH) predominantly affect females through an unknown mechanism. Activity of the serotonin transporter (SERT) may modulate the development of PAH, and...
12.
In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension
Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, et al.
Cardiovasc Res
. 2009 Sep;
85(3):593-603.
PMID: 19736308
Aims: A mechanism for co-operation between the serotonin (5-hydroxytryptamine, 5-HT) transporter and 5-HT1B receptor in mediating pulmonary artery vasoconstriction and proliferation of pulmonary artery smooth muscle cells has been demonstrated...
13.
Dempsie Y, Morecroft I, Welsh D, MacRitchie N, Herold N, Loughlin L, et al.
Circulation
. 2008 May;
117(22):2928-37.
PMID: 18506000
Background: The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the "serotonin hypothesis" of pulmonary arterial hypertension; however,...
14.
Morecroft I, Dempsie Y, Bader M, Walther D, Kotnik K, Loughlin L, et al.
Hypertension
. 2006 Nov;
49(1):232-6.
PMID: 17130306
Tryptophan hydroxylase 1 catalyzes the rate-limiting step in the synthesis of serotonin in the periphery. Recently, it has been shown that expression of the tryptophan hydroxylase 1 gene is increased...
15.
Morecroft I, Loughlin L, Nilsen M, Colston J, Dempsie Y, Sheward J, et al.
J Pharmacol Exp Ther
. 2005 Jan;
313(2):539-48.
PMID: 15659538
Pulmonary arterial 5-hydroxytryptamine (serotonin) (5-HT) transporter (SERT)-, 5-HT receptor expression, and 5-HT-induced vasoconstriction can be increased in pulmonary hypertension. These variables were studied in normoxic and hypoxic Fawn-Hooded (FH) and...
16.
MacLean M, Deuchar G, Hicks M, Morecroft I, Shen S, Sheward J, et al.
Circulation
. 2004 Apr;
109(17):2150-5.
PMID: 15078799
Background: Increased serotonin (5-hydroxytryptamine, 5-HT) transporter activity has been observed in human familial pulmonary hypertension. Methods And Results: We investigated pulmonary hemodynamics and the development of hypoxia-induced pulmonary hypertension and...