Luke Ajay David
Overview
Explore the profile of Luke Ajay David including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
87
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0
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Recent Articles
1.
Touahri Y, Hanna J, Tachibana N, Okawa S, Liu H, David L, et al.
Cell Rep
. 2024 Mar;
43(4):114005.
PMID: 38551961
The retina is exquisitely patterned, with neuronal somata positioned at regular intervals to completely sample the visual field. Here, we show that phosphatase and tensin homolog (Pten) controls starburst amacrine...
2.
Boudreau-Pinsonneault C, David L, Lourenco Fernandes J, Javed A, Fries M, Mattar P, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2122168120.
PMID: 37126716
Temporal identity factors are sufficient to reprogram developmental competence of neural progenitors and shift cell fate output, but whether they can also reprogram the identity of terminally differentiated cells is...
3.
Santos-Franca P, David L, Kassem F, Meng X, Cayouette M
Semin Cell Dev Biol
. 2022 Jun;
142:36-42.
PMID: 35760728
Understanding how retinal progenitor cells (RPCs) give rise to the variety of neural cell types of the retina has been a question of major interest over the last few decades....
4.
Hanna J, David L, Touahri Y, Fleming T, Screaton R, Schuurmans C
Front Cell Dev Biol
. 2022 Jun;
10:887764.
PMID: 35663397
Vision commences in the retina with rod and cone photoreceptors that detect and convert light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative disease leads to visual...
5.
Han S, Okawa S, Wilkinson G, Ghazale H, Adnani L, Dixit R, et al.
Neuron
. 2021 Aug;
109(18):2847-2863.e11.
PMID: 34407390
Asymmetric neuronal expansion is thought to drive evolutionary transitions between lissencephalic and gyrencephalic cerebral cortices. We report that Neurog2 and Ascl1 proneural genes together sustain neurogenic continuity and lissencephaly in...
6.
Vasan L, Park E, David L, Fleming T, Schuurmans C
Front Cell Dev Biol
. 2021 Jul;
9:681087.
PMID: 34291049
Direct neuronal reprogramming is an innovative new technology that involves the conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent state. The capacity to make new...
7.
Touahri Y, Dixit R, Kofoed R, Miloska K, Park E, Raeisossadati R, et al.
Theranostics
. 2020 Mar;
10(7):2982-2999.
PMID: 32194850
Müller glia are specialized retinal cells with stem cell properties in fish and frogs but not in mammals. Current efforts to develop gene therapies to activate mammalian Müller glia for...
8.
Tachibana N, Touahri Y, Dixit R, David L, Adnani L, Cantrup R, et al.
Dis Model Mech
. 2018 May;
11(5).
PMID: 29716894
hamartoma tumour syndrome (PHTS) is a heterogeneous group of rare, autosomal dominant disorders associated with germline mutations. PHTS patients routinely develop hamartomas, which are benign tissue overgrowths comprised of disorganized...