Lucy S Jun
Overview
Explore the profile of Lucy S Jun including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
316
Followers
0
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Recent Articles
1.
Barry P, Mall M, Alvarez A, Colombo C, de Winter-de Groot K, Fajac I, et al.
N Engl J Med
. 2021 Aug;
385(9):815-825.
PMID: 34437784
Background: Elexacaftor-tezacaftor-ivacaftor is a small-molecule cystic fibrosis transmembrane conductance regulator (CFTR) modulator regimen shown to be efficacious in patients with at least one allele, which indicates that this combination can...
2.
Apgar J, Tang J, Singh P, Balasubramanian N, Burke J, Hodges M, et al.
CPT Pharmacometrics Syst Pharmacol
. 2018 Apr;
7(6):404-412.
PMID: 29637732
Crigler-Najjar syndrome type 1 (CN1) is an autosomal recessive disease caused by a marked decrease in uridine-diphosphate-glucuronosyltransferase (UGT1A1) enzyme activity. Delivery of hUGT1A1-modRNA (a modified messenger RNA encoding for UGT1A1)...
3.
Roseman D, Khan T, Rajas F, Jun L, Asrani K, Isaacs C, et al.
Mol Ther
. 2018 Feb;
26(3):814-821.
PMID: 29428299
Glycogen storage disease type Ia (GSD1a) is an inherited metabolic disorder caused by the deficiency of glucose-6-phosphatase (G6Pase). GSD1a is associated with life-threatening hypoglycemia and long-term liver and renal complications....
4.
Jun L, Showalter A, Ali N, Dai F, Ma W, Coskun T, et al.
PLoS One
. 2015 Jul;
10(7):e0132875.
PMID: 26172935
No abstract available.
5.
Jun L, Millican R, Hawkins E, Konkol D, Showalter A, Christe M, et al.
Diabetes
. 2014 Oct;
64(3):819-27.
PMID: 25288673
The absence of insulin results in oscillating hyperglycemia and ketoacidosis in type 1 diabetes. Remarkably, mice genetically deficient in the glucagon receptor (Gcgr) are refractory to the pathophysiological symptoms of...
6.
Prentice K, Luu L, Allister E, Liu Y, Jun L, Sloop K, et al.
Cell Metab
. 2014 Apr;
19(4):653-66.
PMID: 24703697
Gestational diabetes (GDM) results from failure of the β cells to adapt to increased metabolic demands; however, the cause of GDM and the extremely high rate of progression to type...
7.
Jun L, Showalter A, Ali N, Dai F, Ma W, Coskun T, et al.
PLoS One
. 2014 Apr;
9(4):e93746.
PMID: 24695667
Class B G protein-coupled receptors (GPCRs) are important regulators of endocrine physiology, and peptide-based therapeutics targeting some of these receptors have proven effective at treating disorders such as hypercalcemia, osteoporosis,...
8.
Jun L, Siddall C, Rosen E
Am J Physiol Endocrinol Metab
. 2011 Jul;
301(5):E825-35.
PMID: 21771968
Adipose tissue controls energy homeostasis and systemic insulin sensitivity through the elaboration of a series of cytokines and hormones, collectively termed "adipokines." We and others have identified Lcn2 as a...