Lucita Jimenez
Overview
Explore the profile of Lucita Jimenez including associated specialties, affiliations and a list of published articles.
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11
Citations
226
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Recent Articles
1.
Wnorowski A, Sadowska M, Paul R, Singh N, Boguszewska-Czubara A, Jimenez L, et al.
Cell Signal
. 2015 Feb;
27(5):997-1007.
PMID: 25703025
(R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a highly-selective β2 adrenergic receptor (β2-AR) agonist. Incubation of a panel of human-derived melanoma cell lines with (R,R')-MNF resulted in a dose- and time-dependent inhibition of motility...
2.
Woo A, Jozwiak K, Toll L, Tanga M, Kozocas J, Jimenez L, et al.
J Biol Chem
. 2014 May;
289(28):19351-63.
PMID: 24831005
Interaction of a given G protein-coupled receptor to multiple different G proteins is a widespread phenomenon. For instance, β2-adrenoceptor (β2-AR) couples dually to Gs and Gi proteins. Previous studies have...
3.
Plazinska A, Pajak K, Rutkowska E, Jimenez L, Kozocas J, Koolpe G, et al.
Bioorg Med Chem
. 2013 Dec;
22(1):234-46.
PMID: 24326276
The β₂-adrenergic receptor (β₂-AR) agonist [(3)H]-(R,R')-methoxyfenoterol was employed as the marker ligand in displacement studies measuring the binding affinities (Ki values) of the stereoisomers of a series of 4'-methoxyfenoterol analogs...
4.
Moaddel R, Abdrakhmanova G, Kozak J, Jozwiak K, Toll L, Jimenez L, et al.
Eur J Pharmacol
. 2012 Nov;
698(1-3):228-34.
PMID: 23183107
The effect of the (R,S)-ketamine metabolites (R,S)-norketamine, (R,S)-dehydronorketamine, (2S,6S)-hydroxynorketamine and (2R,6R)-hydroxynorketamine on the activity of α7 and α3β4 neuronal nicotinic acetylcholine receptors was investigated using patch-clamp techniques. The data indicated...
5.
Paul R, Ramamoorthy A, Scheers J, Wersto R, Toll L, Jimenez L, et al.
J Pharmacol Exp Ther
. 2012 Jul;
343(1):157-66.
PMID: 22776956
Inhibition of cell proliferation by fenoterol and fenoterol derivatives in 1321N1 astrocytoma cells is consistent with β(2)-adrenergic receptor (β(2)-AR) stimulation. However, the events that result in fenoterol-mediated control of cell...
6.
Toll L, Pajak K, Plazinska A, Jozwiak K, Jimenez L, Kozocas J, et al.
Mol Pharmacol
. 2012 Mar;
81(6):846-54.
PMID: 22434858
G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intracellular components....
7.
Jozwiak K, Plazinska A, Toll L, Jimenez L, Woo A, Xiao R, et al.
Chirality
. 2011 May;
23 Suppl 1:E1-6.
PMID: 21618615
The β(2) adrenergic receptor (β(2)-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β(2)-AR selective agonist that has two centers...
8.
Jozwiak K, Toll L, Jimenez L, Woo A, Xiao R, Wainer I
Biochem Pharmacol
. 2010 Feb;
79(11):1610-5.
PMID: 20144591
The binding thermodynamics of the stereoisomers of fenoterol, (R,R')-, (S,S')-, (R,S')-, and (S,R')-fenoterol, to the beta(2)-adrenergic receptor (beta(2)-AR) have been determined. The experiments utilized membranes obtained from HEK cells stably...
9.
Jozwiak K, Woo A, Tanga M, Toll L, Jimenez L, Kozocas J, et al.
Bioorg Med Chem
. 2009 Dec;
18(2):728-36.
PMID: 20036561
Purpose: To use a previously developed CoMFA model to design a series of new structures of high selectivity and efficacy towards the beta(2)-adrenergic receptor. Results: Out of 21 computationally designed...
10.
Jozwiak K, Khalid C, Tanga M, Berzetei-Gurske I, Jimenez L, Kozocas J, et al.
J Med Chem
. 2007 May;
50(12):2903-15.
PMID: 17506540
Stereoisomers of fenoterol and six fenoterol derivatives have been synthesized and their binding affinities for the beta2 adrenergic receptor (Kibeta2-AR), the subtype selectivity relative to the beta1-AR (Kibeta1-AR/Kibeta2-AR) and their...