Lucio H Castilla
Overview
Explore the profile of Lucio H Castilla including associated specialties, affiliations and a list of published articles.
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24
Citations
589
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Recent Articles
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Mohammadhosseini M, Enright T, Duvall A, Chitsazan A, Lin H, Ors A, et al.
Sci Transl Med
. 2025 Jan;
17(780):eadn9832.
PMID: 39772771
Familial platelet disorder (FPD) is associated with germline mutations, establishing a preleukemic state and increasing the risk of developing leukemia. Currently, there are no intervention strategies to prevent leukemia progression....
3.
Hegde M, Ahmad M, Mulet Lazaro R, Sugita M, Li R, Hu K, et al.
Leukemia
. 2024 Nov;
39(2):360-370.
PMID: 39572712
Oncogenic programs regulate the proliferation and maintenance of cancer stem cells, and can define pharmacologic dependencies. In acute myeloid leukemia (AML) with the chromosome inversion 16 (inv(16)), the fusion oncoprotein ...
4.
Roderick-Richardson J, Lim S, Suzuki S, Ahmad M, Selway J, Suleiman R, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(4):e2309628121.
PMID: 38227660
Human bone marrow failure (BMF) syndromes result from the loss of hematopoietic stem and progenitor cells (HSPC), and this loss has been attributed to cell death; however, the cell death...
5.
Ahmad M, Hegde M, Wong W, Mohammadhosseini M, Garrett L, Carrascoso A, et al.
Blood Adv
. 2023 Sep;
7(23):7304-7318.
PMID: 37756546
Germ line mutations in the RUNX1 gene cause familial platelet disorder (FPD), an inherited disease associated with lifetime risk to hematopoietic malignancies (HM). Patients with FPD frequently show clonal expansion...
6.
Zezulin A, Yen D, Ye D, Howell E, Bresciani E, Diemer J, et al.
Genes Dev
. 2023 Aug;
37(13-14):605-620.
PMID: 37536952
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancy (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 was shown to regulate inflammation in multiple...
7.
Zezulin A, Ye D, Howell E, Yen D, Bresciani E, Diemer J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747636
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancies (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 regulates inflammation in multiple cell types. Here...
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9.
Ou J, Liu H, Yu J, Kelliher M, Castilla L, Lawson N, et al.
BMC Genomics
. 2018 Mar;
19(1):169.
PMID: 29490630
Background: ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing) is a recently developed technique for genome-wide analysis of chromatin accessibility. Compared to earlier methods for assaying chromatin accessibility, ATAC-seq is faster...
10.
Illendula A, Gilmour J, Grembecka J, Tirumala V, Boulton A, Kuntimaddi A, et al.
EBioMedicine
. 2017 Nov;
25:188.
PMID: 29104075
No abstract available.