P Paul Liu
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Explore the profile of P Paul Liu including associated specialties, affiliations and a list of published articles.
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41
Citations
1411
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Recent Articles
1.
Ahmad M, Hegde M, Wong W, Mohammadhosseini M, Garrett L, Carrascoso A, et al.
Blood Adv
. 2023 Sep;
7(23):7304-7318.
PMID: 37756546
Germ line mutations in the RUNX1 gene cause familial platelet disorder (FPD), an inherited disease associated with lifetime risk to hematopoietic malignancies (HM). Patients with FPD frequently show clonal expansion...
2.
Zezulin A, Yen D, Ye D, Howell E, Bresciani E, Diemer J, et al.
Genes Dev
. 2023 Aug;
37(13-14):605-620.
PMID: 37536952
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancy (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 was shown to regulate inflammation in multiple...
3.
Zezulin A, Ye D, Howell E, Yen D, Bresciani E, Diemer J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747636
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancies (FPDMM) and in sporadic myelodysplastic syndrome and leukemia. RUNX1 regulates inflammation in multiple cell types. Here...
4.
Zhen T, Cao Y, Ren G, Zhao L, Hyde R, Lopez G, et al.
Blood
. 2020 Sep;
136(21):2373-2385.
PMID: 32929473
Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a CBFB-MYH11 fusion gene. It is generally considered that CBFβ-SMMHC,...
5.
Hsu J, Huang H, Lee C, Choudhuri A, Wilson N, Abraham B, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23626-23635.
PMID: 32883883
Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7...
6.
McElderry J, Carrington B, Bishop K, Kim E, Pei W, Chen Z, et al.
Hum Mol Genet
. 2019 Nov;
28(24):4173-4185.
PMID: 31691804
DHX15, a DEAH box containing RNA helicase, is a splicing factor required for the last step of splicing. Recent studies identified a recurrent mutational hotspot, R222G, in DHX15 in ∼ ...
7.
Hall A, Choi K, Liu W, Rose J, Zhao C, Yu Y, et al.
Sci Adv
. 2019 Apr;
5(4):eaau8389.
PMID: 31032403
Patients with neurofibromatosis type 1 (NF1) are predisposed to develop neurofibromas, but the underlying molecular mechanisms of neurofibromagenesis are not fully understood. We showed dual genetic deletion of and in...
8.
Zhen T, Kwon E, Zhao L, Hsu J, Hyde R, Lu Y, et al.
Blood
. 2017 Oct;
130(22):2431-2442.
PMID: 29018080
Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which generates a fusion gene. Previous studies showed that the interaction between...
9.
Cai T, Chen X, Li J, Xiang B, Yang L, Liu Y, et al.
Am J Hematol
. 2017 Sep;
92(12):E653-E656.
PMID: 28891213
No abstract available.
10.
Connelly J, Kwon E, Gao Y, Trivedi N, Elkahloun A, Horwitz M, et al.
Blood
. 2014 Aug;
124(12):1926-30.
PMID: 25114263
Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disease of the hematopoietic system that is caused by heterozygous mutations in RUNX1. FPD/AML patients have...