Lucie Valek
Overview
Explore the profile of Lucie Valek including associated specialties, affiliations and a list of published articles.
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17
Citations
153
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Recent Articles
1.
Valek L, Tran B, Tegeder I
Free Radic Biol Med
. 2022 Sep;
192:84-97.
PMID: 36126861
Nucleoredoxin is a thioredoxin-like oxidoreductase that mainly acts as oxidase and thereby regulates calcium calmodulin kinase Camk2a, an effector of nitric oxide mediated synaptic potentiation and nociceptive sensitization. We asked...
2.
Valek L, Tegeder I
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502404
Rodent models of Parkinson's disease are based on transgenic expression of mutant synuclein, deletion of PD genes, injections of MPTP or rotenone, or seeding of synuclein fibrils. The models show...
3.
Tran B, Valek L, Wilken-Schmitz A, Fuhrmann D, Namgaladze D, Wittig I, et al.
Redox Biol
. 2021 Jul;
45:102054.
PMID: 34198070
Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a, Camk2a, as a prominent prey...
4.
Valek L, Tran B, Wilken-Schmitz A, Trautmann S, Heidler J, Schmid T, et al.
Neuropathol Appl Neurobiol
. 2021 May;
47(7):1060-1079.
PMID: 33974284
Aims: Parkinson's disease (PD) is frequently associated with a prodromal sensory neuropathy manifesting with sensory loss and chronic pain. We have recently shown that PD-associated sensory neuropathy in patients is...
5.
Valek L, Tegeder I
Antioxidants (Basel)
. 2021 Apr;
10(3).
PMID: 33805811
Nucleoredoxin (NXN) is a redox regulator of Disheveled and thereby of WNT signaling. Deficiency in mice leads to cranial dysmorphisms and defects of heart, brain, and bone, suggesting defects of...
6.
High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease
Klatt-Schreiner K, Valek L, Kang J, Khlebtovsky A, Trautmann S, Hahnefeld L, et al.
Mov Disord
. 2020 Jul;
35(10):1822-1833.
PMID: 32652698
Background: Parkinson's disease (PD) causes chronic pain in two-thirds of patients, in part originating from sensory neuropathies. The aim of the present study was to describe the phenotype of PD-associated...
7.
Valek L, Auburger G, Tegeder I
Dis Model Mech
. 2019 Jun;
12(6).
PMID: 31248900
Parkinson's disease (PD) often manifests with prodromal pain and sensory losses whose etiologies are not well understood. Multiple genetic and toxicity-based rodent models of PD partly recapitulate the histopathology and...
8.
Heidler J, Valek L, Wittig I, Tegeder I
Data Brief
. 2018 Nov;
21:1309-1314.
PMID: 30456249
Upregulations of neuronal nitric oxide synthase (nNOS/NOS1) in the mouse brain upon aging suggest a role in age-associated changes of protein homeostasis. We generated a cell model, in which constitutive...
9.
Heidler J, Valek L, Wittig I, Tegeder I
Data Brief
. 2018 Nov;
21:1302-1308.
PMID: 30456248
Upregulations of neuronal nitric oxide synthase (nNOS/NOS1) in the mouse brain upon aging and stress suggest a role of NO-dependent redox protein modifications for age-associated protein imbalances or dysfunctions. We...
10.
Valek L, Heidler J, Scheving R, Wittig I, Tegeder I
Redox Biol
. 2018 Oct;
20:217-235.
PMID: 30368041
Upregulations of neuronal nitric oxide synthase (nNOS) in the rodent brain have been associated with neuronal aging. To address underlying mechanisms we generated SH-SY5Y neuronal cells constitutively expressing nNOS at...