Lucia Schwarzfischer
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Explore the profile of Lucia Schwarzfischer including associated specialties, affiliations and a list of published articles.
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12
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2083
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Recent Articles
1.
Gebhard C, Glatz D, Schwarzfischer L, Wimmer J, Stasik S, Nuetzel M, et al.
Leukemia
. 2018 Jun;
33(1):26-36.
PMID: 29925905
Malignant transformation is frequently associated with disease-specific epigenetic alterations, but the underlying mechanisms and pathophysiological consequences remain poorly understood. Here, we used global comparative DNA methylation profiling at CG-rich regions...
2.
Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, et al.
Nature
. 2014 Mar;
507(7493):455-461.
PMID: 24670763
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and...
3.
Pham T, Benner C, Lichtinger M, Schwarzfischer L, Hu Y, Andreesen R, et al.
Blood
. 2012 May;
119(24):e161-71.
PMID: 22550342
Cellular differentiation is orchestrated by lineage-specific transcription factors and associated with cell type-specific epigenetic signatures. In the present study, we used stage-specific, epigenetic "fingerprints" to deduce key transcriptional regulators of...
4.
El Chartouni C, Schwarzfischer L, Rehli M
Immunobiology
. 2010 Jun;
215(9-10):821-5.
PMID: 20580461
Interleukin (IL)-4 is a central regulator of T helper 2 (Th2) immune responses, and also has a major impact on innate immune cells. This cytokine primes macrophages for immune responses...
5.
Klug M, Heinz S, Gebhard C, Schwarzfischer L, Krause S, Andreesen R, et al.
Genome Biol
. 2010 Jun;
11(6):R63.
PMID: 20565882
Background: In mammals, the dynamics of DNA methylation, in particular the regulated, active removal of cytosine methylation, has remained a mystery, partly due to the lack of appropriate model systems...
6.
Gebhard C, Benner C, Ehrich M, Schwarzfischer L, Schilling E, Klug M, et al.
Cancer Res
. 2010 Feb;
70(4):1398-407.
PMID: 20145141
Aberrant DNA methylation at CpG islands is thought to contribute to cancer initiation and progression, but mechanisms that establish and maintain DNA methylation status during tumorigenesis or normal development remain...
7.
Pham T, Langmann S, Schwarzfischer L, El Chartouni C, Lichtinger M, Klug M, et al.
J Biol Chem
. 2007 Jun;
282(30):21924-33.
PMID: 17540774
Human monocyte to macrophage differentiation is accompanied by pronounced phenotypical changes and generally proceeds in the absence of proliferation. The molecular events governing this process are poorly understood. Here, we...
8.
Gebhard C, Schwarzfischer L, Pham T, Andreesen R, Mackensen A, Rehli M
Nucleic Acids Res
. 2006 Jul;
34(11):e82.
PMID: 16822855
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. We have developed a novel technique for detecting CpG-methylated...
9.
Gebhard C, Schwarzfischer L, Pham T, Schilling E, Klug M, Andreesen R, et al.
Cancer Res
. 2006 Jun;
66(12):6118-28.
PMID: 16778185
The methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes. Because aberrant hypermethylation may be used as a...
10.
Rehli M, Niller H, Ammon C, Langmann S, Schwarzfischer L, Andreesen R, et al.
J Biol Chem
. 2003 Aug;
278(45):44058-67.
PMID: 12933821
The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyte/macrophage...