Lucas Bottcher
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Explore the profile of Lucas Bottcher including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
126
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Recent Articles
1.
Bottcher L, Fonseca L, Laubenbacher R
Philos Trans A Math Phys Eng Sci
. 2025 Mar;
383(2292):20240228.
PMID: 40078154
The objective of precision medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology...
2.
Fonseca L, Bottcher L, Mehrad B, Laubenbacher R
PLoS Comput Biol
. 2025 Jan;
21(1):e1012138.
PMID: 39808665
This paper describes and validates an algorithm to solve optimal control problems for agent-based models (ABMs). For a given ABM and a given optimal control problem, the algorithm derives a...
3.
Bottcher L, DOrsogna M, Chou T
PLoS Comput Biol
. 2025 Jan;
21(1):e1012749.
PMID: 39775197
Gathering observational data for medical decision-making often involves uncertainties arising from both type I (false positive) and type II (false negative) errors. In this work, we develop a statistical model...
4.
Owusu-Boaitey N, Bottcher L, He D, Erkhembayar R, Yang L, Kim D, et al.
Infect Dis (Lond)
. 2024 Aug;
56(10):897-902.
PMID: 39133617
Public health systems reported low mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in East Asia, in low-income countries, and for children during the first year of the SARS-CoV-2...
5.
Fonseca L, Bottcher L, Mehrad B, Laubenbacher R
ArXiv
. 2024 Jun;
PMID: 38827450
The vision of personalized medicine is to identify interventions that maintain or restore a person's health based on their individual biology. Medical digital twins, computational models that integrate a wide...
6.
Bottcher L, Chou T, DOrsogna M
PNAS Nexus
. 2024 May;
3(2):pgae050.
PMID: 38725534
The drug-overdose crisis in the United States continues to intensify. Fatalities have increased 5-fold since 1999 reaching a record high of 108,000 deaths in 2021. The epidemic has unfolded through...
7.
Bottcher L, Fonseca L, Laubenbacher R
bioRxiv
. 2024 Apr;
PMID: 38562787
The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology...
8.
Bottcher L, Fonseca L, Laubenbacher R
ArXiv
. 2024 Apr;
PMID: 38562447
The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology...
9.
Bottcher L, Porter M
Phys Rev E
. 2024 Mar;
109(2-1):024314.
PMID: 38491610
In many studies, it is common to use binary (i.e., unweighted) edges to examine networks of entities that are either adjacent or not adjacent. Researchers have generalized such binary networks...
10.
Bottcher L, Breedvelt J, Warren F, Segal Z, Kuyken W, Bockting C
BMC Psychiatry
. 2023 Nov;
23(1):835.
PMID: 37957596
Background: Depression is a highly common and recurrent condition. Predicting who is at most risk of relapse or recurrence can inform clinical practice. Applying machine-learning methods to Individual Participant Data...