Tom Chou
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Explore the profile of Tom Chou including associated specialties, affiliations and a list of published articles.
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102
Citations
827
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Recent Articles
1.
Xia M, Chou T
Phys Rev E
. 2025 Feb;
110(6-1):064146.
PMID: 39916132
We formulate a general, high-dimensional, partial integrodifferential equation (PIDE) kinetic theory describing the internal state (such as gene expression or protein levels) of cells in a stochastically evolving population. The...
2.
Bottcher L, DOrsogna M, Chou T
PLoS Comput Biol
. 2025 Jan;
21(1):e1012749.
PMID: 39775197
Gathering observational data for medical decision-making often involves uncertainties arising from both type I (false positive) and type II (false negative) errors. In this work, we develop a statistical model...
3.
Li X, Chou T
PLoS Comput Biol
. 2024 Jun;
20(6):e1012183.
PMID: 38857304
Cellular signaling, crucial for biological processes like immune response and homeostasis, relies on specificity and fidelity in signal transduction to accurately respond to stimuli amidst biological noise. Kinetic proofreading (KPR)...
4.
Bottcher L, Chou T, DOrsogna M
PNAS Nexus
. 2024 May;
3(2):pgae050.
PMID: 38725534
The drug-overdose crisis in the United States continues to intensify. Fatalities have increased 5-fold since 1999 reaching a record high of 108,000 deaths in 2021. The epidemic has unfolded through...
5.
Mao S, Chou T, DOrsogna M
Math Biosci
. 2024 Apr;
372:109184.
PMID: 38582296
More than 60% of individuals recovering from substance use disorder relapse within one year. Some will resume drug consumption even after decades of abstinence. The cognitive and psychological mechanisms that...
6.
Wang Y, Shtylla B, Chou T
Bull Math Biol
. 2024 Feb;
86(3):32.
PMID: 38363386
In some patients with myeloproliferative neoplasms (MPN), two genetic mutations are often found: JAK2 V617F and one in the TET2 gene. Whether one mutation is present influences how the other...
7.
Li X, Chou T
J Chem Phys
. 2023 Nov;
159(20).
PMID: 38010331
We construct and analyze monomeric and multimeric models of the stochastic disassembly of a single nucleosome. Our monomeric model predicts the time needed for a number of histone-DNA contacts to...
8.
Li X, Habibipour S, Chou T, Yang O
Virus Evol
. 2023 Oct;
9(2):vead058.
PMID: 37841642
Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing compared to MPXV genomes collected earlier. It is...
9.
Li X, Chou T
ArXiv
. 2023 Sep;
PMID: 37731652
We construct and analyze monomeric and multimeric models of the stochastic disassembly of a single nucleosome. Our monomeric model predicts the time needed for a number of histone-DNA contacts to...
10.
Bottcher L, Wald S, Chou T
Bull Math Biol
. 2023 Sep;
85(10):102.
PMID: 37707621
Diverse T and B cell repertoires play an important role in mounting effective immune responses against a wide range of pathogens and malignant cells. The number of unique T and...