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Lucas B Sullivan

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Articles 48
Citations 4467
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Recent Articles
1.
Newsom O, Sullivan L
bioRxiv . 2025 Mar; PMID: 40027810
Fetal bovine serum (FBS) is a nearly ubiquitous, yet undefined additive in mammalian cell culture media whose functional contributions to promoting cell proliferation remain poorly understood. Efforts to replace serum...
2.
Hart M, Davidsen K, Danquah S, Zheng E, Sokolov D, Sullivan L
bioRxiv . 2025 Mar; PMID: 40027747
Impaired availability of the amino acid aspartate can be a metabolic constraint of cell proliferation in diverse biological contexts. However, the kinetics of aspartate depletion, and its ramifications on downstream...
3.
Sokolov D, Sullivan L
Life Metab . 2025 Jan; 3(1):load046. PMID: 39871876
No abstract available.
4.
Davidsen K, Sullivan L
Elife . 2024 Jul; 12. PMID: 39076160
Current methods to quantify the fraction of aminoacylated tRNAs, also known as the tRNA charge, are limited by issues with either low throughput, precision, and/or accuracy. Here, we present an...
5.
Sokolov D, Sullivan L
Mol Cell . 2024 Jul; 84(13):2407-2409. PMID: 38996457
In two recent studies appearing in Cell and Cell Metabolism, Tran et al. and Wu et al. describe underappreciated nuance in organismal and cellular purine nucleotide salvage pathways and identify...
6.
Maurice N, Erickson J, DeJong C, Mair F, Taber A, Frutoso M, et al.
bioRxiv . 2024 Jun; PMID: 38915597
Placentation presents immune conflict between mother and fetus, yet in normal pregnancy maternal immunity against infection is maintained without expense to fetal tolerance. This is believed to result from adaptations...
7.
Cranmer L, Konnick E, Yoshida J, Jacobson A, Malik B, Mogal H, et al.
JCO Precis Oncol . 2024 Jun; 8:e2300455. PMID: 38885448
Highlighting here a patient case with neuroblastoma, renal cancer & GIST from germline SDHA.
8.
Marsh N, MacEwen M, Chea J, Kenerson H, Kwong A, Locke T, et al.
bioRxiv . 2024 Jun; PMID: 38853984
Metabolic adaptations in response to changes in energy supply and demand are essential for survival. The mitochondrial calcium uniporter plays a key role in coordinating metabolic homeostasis by regulating TCA...
9.
Luk I, Bridgwater C, Yu A, Boila L, Yanez-Bartolome M, Lampano A, et al.
Sci Transl Med . 2024 May; 16(747):eadj7685. PMID: 38748774
Intrahepatic cholangiocarcinoma (ICC) is an aggressive bile duct malignancy that frequently exhibits isocitrate dehydrogenase () mutations. Mutant IDH (IDHm) ICC is dependent on SRC kinase for growth and survival and...
10.
Uo T, Ojo K, Sprenger C, Epilepsia K, Perera B, Damodarasamy M, et al.
Mol Cancer Ther . 2024 Mar; 23(7):973-994. PMID: 38507737
Metastatic castration-resistant prostate cancer remains incurable regardless of recent therapeutic advances. Prostate cancer tumors display highly glycolytic phenotypes as the cancer progresses. Nonspecific inhibitors of glycolysis have not been utilized...