Lucas B Sullivan
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Explore the profile of Lucas B Sullivan including associated specialties, affiliations and a list of published articles.
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48
Citations
4467
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Recent Articles
11.
Davidsen K, Marvin J, Aggarwal A, Brown T, Sullivan L
Elife
. 2024 Feb;
12.
PMID: 38393319
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure...
12.
Jaeger-Ruckstuhl C, Lo Y, Fulton E, Waltner O, Shabaneh T, Simon S, et al.
Immunity
. 2024 Feb;
57(2):287-302.e12.
PMID: 38354704
The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8 T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is necessary for T cell...
13.
Davidsen K, Sullivan L
bioRxiv
. 2023 Aug;
PMID: 37577502
Current methods to quantify the fraction of aminoacylated tRNAs, also known as the tRNA charge, are limited by issues with either low throughput, precision, and/or accuracy. Here, we present an...
14.
Uo T, Ojo K, Sprenger C, Epilepsia K, Perera B, Damodarasamy M, et al.
bioRxiv
. 2023 Jul;
PMID: 37461469
Purpose: Metastatic castration-resistant prostate cancer remains incurable regardless of recent therapeutic advances. Prostate cancer tumors display highly glycolytic phenotypes as the cancer progresses. Non-specific inhibitors of glycolysis have not been...
15.
Davidsen K, Marvin J, Aggarwal A, Brown T, Sullivan L
bioRxiv
. 2023 Jul;
PMID: 37425831
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure...
16.
Nguyen H, Tang W, Webster A, Whiteaker J, Chandler C, Errazquin R, et al.
Int J Cancer
. 2023 Mar;
153(1):183-196.
PMID: 36912284
Fanconi anemia (FA) is a heritable malformation, bone marrow failure and cancer predisposition syndrome that confers an exceptionally high risk of squamous carcinomas. These carcinomas originate in epithelia lining the...
17.
Hart M, Quon E, Vigil A, Engstrom I, Newsom O, Davidsen K, et al.
Elife
. 2023 Mar;
12.
PMID: 36883551
The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation....
18.
Kinsella S, Evandy C, Cooper K, Cardinale A, Iovino L, deRoos P, et al.
bioRxiv
. 2023 Jan;
PMID: 36711570
Endogenous thymic regeneration is a crucial process that allows for the renewal of immune competence following stress, infection or cytoreductive conditioning. Fully understanding the molecular mechanisms driving regeneration will uncover...
19.
Newsom O, Sullivan L
Cell Metab
. 2022 Nov;
34(11):1617-1619.
PMID: 36323232
Metabolic disruption is a mainstay of cancer therapy, prompting research aimed at identifying novel metabolic targets. Despite strong effects observed in culture, three recent studies found pancreatic tumors are refractory...
20.
Li Z, Ji B, Dixit P, Tchourine K, Lien E, Hosios A, et al.
Nat Metab
. 2022 Jun;
4(6):711-723.
PMID: 35739397
Production of oxidized biomass, which requires regeneration of the cofactor NAD, can be a proliferation bottleneck that is influenced by environmental conditions. However, a comprehensive quantitative understanding of metabolic processes...