Luc Alexis Leuthold
Overview
Explore the profile of Luc Alexis Leuthold including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
101
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Recent Articles
1.
Glaenzel U, Huth F, Eggimann F, Hackling M, Leuthold L, Meissner A, et al.
Drug Metab Dispos
. 2024 Sep;
52(12):1379-1387.
PMID: 39313328
Icenticaftor (QBW251) is a potentiator of the cystic fibrosis transmembrane conductance regulator protein and is currently in clinical development for the treatment of chronic obstructive pulmonary disease and chronic bronchitis....
2.
Poller B, Pearson D, Leuthold L, Fink M, Jullion A, Schweigler P, et al.
Drug Metab Dispos
. 2022 Oct;
50(12):1472-1482.
PMID: 36195338
LYS006 is a potent leukotriene A4 hydrolase inhibitor currently in clinical development for long-term treatment of various neutrophil-driven inflammatory conditions. Here, we present pharmacokinetics from the first-in-human study with complementary...
3.
Maass K, Barfield M, Ito M, James C, Kavetska O, Kozinn M, et al.
Clin Transl Sci
. 2022 Sep;
15(12):2785-2795.
PMID: 36129129
Advances in the technologies to enable patient-centric sampling (PCS) have the potential to improve blood sample collection by enabling clinical trial participants to collect samples via self-collection or with the...
4.
Deglon J, Leuthold L, Thomas A
Bioanalysis
. 2015 Sep;
7(18):2375-2385.
PMID: 26378369
Microsampling, mainly as DBS, has been significantly expanded in the biomedical and pharmaceutical communities in the last 10 years. In parallel, technology and methodology have evolved to overcome some of...
5.
Lanshoeft C, Heudi O, Raccuglia M, Leuthold L, Picard F, Kretz O
Bioanalysis
. 2015 Mar;
7(4):425-35.
PMID: 25747762
Aim: An ultrafast, sensitive, selective and robust LDTD-APCI-MS/MS method was developed for the quantification of ceritinib in human plasma. Results: Samples were protein precipitated using acetonitrile containing [(13)C6]-ceritinib as internal...
6.
Leuthold L, Heudi O, Deglon J, Raccuglia M, Augsburger M, Picard F, et al.
Anal Chem
. 2015 Jan;
87(4):2068-71.
PMID: 25607538
Hematocrit (Hct) is one of the most critical issues associated with the bioanalytical methods used for dried blood spot (DBS) sample analysis. Because Hct determines the viscosity of blood, it...
7.
Lanshoeft C, Heudi O, Leuthold L, Schlotterbeck G, Elbast W, Picard F, et al.
Anal Bioanal Chem
. 2014 Jun;
406(22):5413-23.
PMID: 24958346
A sensitive and ultra-fast method utilizing the laser diode thermal desorption ion source using atmospheric pressure chemical ionization coupled to tandem mass spectrometry (LDTD-APCI-MS/MS) was developed for the quantitative analysis...
8.
Walles M, Wolf T, Jin Y, Ritzau M, Leuthold L, Krauser J, et al.
Drug Metab Dispos
. 2013 Jun;
41(9):1626-41.
PMID: 23775850
The disposition and biotransformation of (14)C-radiolabeled mavoglurant were investigated in four healthy male subjects after a single oral dose of 200 mg. Blood, plasma, urine, and feces collected over 7...
9.
Leuthold L, Reymond F, Rossier J, Varesio E, Hopfgartner G
Eur J Mass Spectrom (Chichester)
. 2010 Jan;
16(1):47-55.
PMID: 20065514
Disposable plastic electrospray chips are particularly attractive for the automated analysis of organic compounds and organometallic compounds. Automated multi-track chip-based infusion electrospray mass spectrometry of low molecular weight compounds using...
10.
Leuthold L, Mandscheff J, Fathi M, Giroud C, Augsburger M, Varesio E, et al.
Rapid Commun Mass Spectrom
. 2005 Dec;
20(2):103-10.
PMID: 16331738
Desorption electrospray ionization mass spectrometry (DESI-MS) was used as a simple and rapid way to analyze drug tablets and powders without sample preparation. Experiments were performed with a home-made DESI...