Hannah L Klein
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Explore the profile of Hannah L Klein including associated specialties, affiliations and a list of published articles.
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40
Citations
953
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Recent Articles
1.
Sui Y, Epstein A, Dominska M, Zheng D, Petes T, Klein H
Nucleic Acids Res
. 2022 Jun;
50(12):6890-6902.
PMID: 35748861
Ribonucleotides can be incorporated into DNA during replication by the replicative DNA polymerases. These aberrant DNA subunits are efficiently recognized and removed by Ribonucleotide Excision Repair, which is initiated by...
2.
Blake A, Cigarroa A, Klein H, Khattab M, Keating T, Van De Coevering P, et al.
J Vet Intern Med
. 2020 Oct;
34(6):2345-2356.
PMID: 33047396
Background: The fecal microbiota, fecal bile acid concentrations, and abundance of Clostridium perfringens and Clostridium difficile are altered in acute and chronic gastrointestinal disease in adult dogs. However, less is...
3.
Epshtein A, Symington L, Klein H
Methods Mol Biol
. 2020 Aug;
2153:193-200.
PMID: 32840781
Spontaneous and induced mitotic recombinations are driven by lesions such as single-strand nicks and gaps and double-strand breaks in the genome. For regions of the genome that are not repetitive,...
4.
Klein H
Proc Natl Acad Sci U S A
. 2020 May;
117(19):10108-10110.
PMID: 32350136
No abstract available.
5.
6.
Potenski C, Epshtein A, Bianco C, Klein H
DNA Repair (Amst)
. 2019 Apr;
84:102614.
PMID: 30975634
The RNase H2 complex is a conserved heterotrimeric enzyme that degrades RNA:DNA hybrids and promotes excision of rNMPs misincorporated during DNA replication. Failure to remove ribonucleotides from DNA leads to...
7.
Klein H, Ang K, Arkin M, Beckwitt E, Chang Y, Fan J, et al.
Microb Cell
. 2019 Jan;
6(1):65-101.
PMID: 30652106
Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. , many of such changes are studies using reporters for specific types of changes, or through cytological...
8.
Klein H, Bacinskaja G, Che J, Cheblal A, Elango R, Epshtein A, et al.
Microb Cell
. 2019 Jan;
6(1):1-64.
PMID: 30652105
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic...
9.
Klein H
DNA Repair (Amst)
. 2017 Jun;
56:26-32.
PMID: 28629774
Genomic DNA is transiently contaminated with ribonucleotide residues during the process of DNA replication through misincorporation by the replicative DNA polymerases α, δ and ε, and by the normal replication...
10.
Epshtein A, Potenski C, Klein H
Microb Cell
. 2017 Feb;
3(6):248-254.
PMID: 28203566
Ribonucleotides can become embedded in DNA from insertion by DNA polymerases, failure to remove Okazaki fragment primers, R-loops that can prime replication, and RNA/cDNA-mediated recombination. RNA:DNA hybrids are removed by...