Lorenza A DAlessandro
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Explore the profile of Lorenza A DAlessandro including associated specialties, affiliations and a list of published articles.
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12
Citations
248
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Recent Articles
1.
Burbano de Lara S, Kemmer S, Biermayer I, Feiler S, Vlasov A, DAlessandro L, et al.
Mol Syst Biol
. 2024 Jan;
20(3):187-216.
PMID: 38216754
Chronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, metabolic dysfunction-associated steatotic liver disease (MASLD) is gaining importance as the...
2.
Hammad S, Ogris C, Othman A, Erdoesi P, Schmidt-Heck W, Biermayer I, et al.
Cell Death Dis
. 2023 Jul;
14(7):414.
PMID: 37438332
The human liver has a remarkable capacity to regenerate and thus compensate over decades for fibrosis caused by toxic chemicals, drugs, alcohol, or malnutrition. To date, no protective mechanisms have...
3.
DAlessandro L, Klingmuller U, Schilling M
Biochem J
. 2022 Jun;
479(12):1361-1374.
PMID: 35748700
In health and disease, liver cells are continuously exposed to cytokines and growth factors. While individual signal transduction pathways induced by these factors were studied in great detail, the cellular...
4.
Budelmann D, Laue H, Weiss N, Dahmen U, DAlessandro L, Biermayer I, et al.
J Pathol Inform
. 2022 Mar;
13:100001.
PMID: 35242441
Many physiological processes and pathological phenomena in the liver tissue are spatially heterogeneous. At a local scale, biomarkers can be quantified along the axis of the blood flow, from portal...
5.
Sobotta S, Raue A, Huang X, Vanlier J, Junger A, Bohl S, et al.
Front Physiol
. 2017 Oct;
8:775.
PMID: 29062282
IL-6 is a central mediator of the immediate induction of hepatic acute phase proteins (APP) in the liver during infection and after injury, but increased IL-6 activity has been associated...
6.
Iwamoto N, DAlessandro L, Depner S, Hahn B, Kramer B, Lucarelli P, et al.
Sci Signal
. 2016 Feb;
9(413):ra13.
PMID: 26838549
The same pathway, such as the mitogen-activated protein kinase (MAPK) pathway, can produce different cellular responses, depending on stimulus or cell type. We examined the phosphorylation dynamics of the MAPK...
7.
Mueller S, Huard J, Waldow K, Huang X, DAlessandro L, Bohl S, et al.
Mol Syst Biol
. 2015 Jul;
11(3):795.
PMID: 26148348
Liver regeneration is a tightly controlled process mainly achieved by proliferation of usually quiescent hepatocytes. The specific molecular mechanisms ensuring cell division only in response to proliferative signals such as...
8.
DAlessandro L, Samaga R, Maiwald T, Rho S, Bonefas S, Raue A, et al.
PLoS Comput Biol
. 2015 Apr;
11(4):e1004192.
PMID: 25905717
Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations is crucial to predict the impact...
9.
Mleczko-Sanecka K, Roche F, Silva A, Call D, DAlessio F, Ragab A, et al.
Blood
. 2014 Jan;
123(10):1574-85.
PMID: 24385536
The hepatic hormone hepcidin is a key regulator of systemic iron metabolism. Its expression is largely regulated by 2 signaling pathways: the "iron-regulated" bone morphogenetic protein (BMP) and the inflammatory...
10.
DAlessandro L, Meyer R, Klingmuller U
Front Physiol
. 2013 Feb;
4:28.
PMID: 23444340
Hepatocellular carcinomas (HCCs) have different etiology and heterogenic genomic alterations lead to high complexity. The molecular features of HCC have largely been studied by gene expression and proteome profiling focusing...