Lore Becker
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Explore the profile of Lore Becker including associated specialties, affiliations and a list of published articles.
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98
Citations
3262
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Recent Articles
1.
Hasenbein T, Hoelzl S, Smith Z, Gerhardinger C, Gonner M, Aguilar-Pimentel A, et al.
Nat Commun
. 2024 Dec;
15(1):10631.
PMID: 39638999
The lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci...
2.
Ahola S, Pazurek L, Mayer F, Lampe P, Hermans S, Becker L, et al.
Sci Adv
. 2024 Aug;
10(31):eadp0443.
PMID: 39093974
Mitochondrial fusion and fission accompany adaptive responses to stress and altered metabolic demands. Inner membrane fusion and cristae morphogenesis depends on optic atrophy 1 (Opa1), which is expressed in different...
3.
Hones G, Geist D, Wenzek C, Pfluger P, Muller T, Aguilar-Pimentel J, et al.
Endocrinology
. 2024 Jun;
165(8).
PMID: 38889231
Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In...
4.
Giusti S, Pino N, Pannunzio C, Ogando M, Armando N, Garrett L, et al.
Sci Adv
. 2024 May;
10(21):eadj8769.
PMID: 38787942
Circular RNAs (circRNAs) are a large class of noncoding RNAs. Despite the identification of thousands of circular transcripts, the biological significance of most of them remains unexplored, partly because of...
5.
Leu C, Lam D, Salminen A, Wefers B, Becker L, Garrett L, et al.
Sleep
. 2024 Feb;
47(5).
PMID: 38314840
Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable or unpleasant sensations in the legs during rest periods. To relieve these sensations, patients move their legs, causing sleep...
6.
Meinhold M, Verbrugge S, Shi A, Schonfelder M, Becker L, Jaspers R, et al.
Cell Tissue Res
. 2024 Jan;
395(3):271-283.
PMID: 38183459
In skeletal muscle, the Hippo effector Yap promotes satellite cell, myoblast, and rhabdomyoblast proliferation but prevents myogenic differentiation into multinucleated muscle fibres. We previously noted that Yap drives expression of...
7.
Calame D, Guo T, Wang C, Garrett L, Jolly A, Dawood M, et al.
Am J Hum Genet
. 2023 Jul;
110(8):1394-1413.
PMID: 37467750
DExD/H-box RNA helicases (DDX/DHX) are encoded by a large paralogous gene family; in a subset of these human helicase genes, pathogenic variation causes neurodevelopmental disorder (NDD) traits and cancer. DHX9...
8.
Jacobs H, Szibor M, Rathkolb B, da Silva-Buttkus P, Aguilar-Pimentel J, Amarie O, et al.
Biochim Biophys Acta Mol Basis Dis
. 2023 May;
1869(7):166760.
PMID: 37230398
The alternative oxidase, AOX, provides a by-pass of the cytochrome segment of the mitochondrial respiratory chain when the chain is unavailable. AOX is absent from mammals, but AOX from Ciona...
9.
da Silva-Buttkus P, Spielmann N, Klein-Rodewald T, Schutt C, Aguilar-Pimentel A, Amarie O, et al.
Mamm Genome
. 2023 May;
34(2):244-261.
PMID: 37160609
Rare diseases (RDs) are a challenge for medicine due to their heterogeneous clinical manifestations and low prevalence. There is a lack of specific treatments and only a few hundred of...
10.
Stroo E, Janssen L, Sin O, Hogewerf W, Koster M, Harkema L, et al.
Life Sci Alliance
. 2023 May;
6(7).
PMID: 37130781
In age-related neurodegenerative diseases, like Alzheimer's and Parkinson's, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm and human cell models...