Lore Becker
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Explore the profile of Lore Becker including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Thalmeier D, Miller G, Schneltzer E, Hurt A, Hrabe deAngelis M, Becker L, et al.
BMC Neurosci
. 2022 Dec;
23(1):81.
PMID: 36575380
Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hearing...
12.
Xie K, Fuchs H, Scifo E, Liu D, Aziz A, Aguilar-Pimentel J, et al.
Nat Commun
. 2022 Nov;
13(1):6830.
PMID: 36369285
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of...
13.
Maity-Kumar G, Stander L, DeAngelis M, Lee S, Molenaar A, Becker L, et al.
Mol Metab
. 2022 Oct;
66:101616.
PMID: 36270613
Objective: The Allan-Herndon-Dudley syndrome (AHDS) is a severe disease caused by dysfunctional central thyroid hormone transport due to functional loss of the monocarboxylate transporter 8 (MCT8). In this study, we...
14.
Schweizer U, Wirth E, Klopstock T, Holter S, Becker L, Moskovitz J, et al.
Redox Biol
. 2022 Oct;
57:102490.
PMID: 36182809
Mice with constitutive disruption of the Selenop gene have been key to delineate the importance of selenoproteins in neurobiology. However, the phenotype of this mouse model is exquisitely dependent on...
15.
Muller-Eigner A, Sanz-Moreno A, de-Diego I, Venkatasubramani A, Langhammer M, Gerlini R, et al.
Commun Biol
. 2022 May;
5(1):408.
PMID: 35505192
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6,...
16.
Wackerhage H, Vechetti I, Baumert P, Gehlert S, Becker L, Jaspers R, et al.
Sports Med
. 2022 Apr;
52(11):2569-2578.
PMID: 35460513
In 1924, Otto Warburg asked "How does the metabolism of a growing tissue differ from that of a non-growing tissue?" Currently, we know that proliferating healthy and cancer cells reprogramme...
17.
Nezhad F, Riermeier A, Schonfelder M, Becker L, de Angelis M, Wackerhage H
Transgenic Res
. 2022 Jan;
31(2):227-237.
PMID: 34984591
The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes...
18.
Garrett L, da Silva-Buttkus P, Rathkolb B, Gerlini R, Becker L, Sanz-Moreno A, et al.
Dis Model Mech
. 2021 Dec;
15(3).
PMID: 34964047
Understanding the shared genetic aetiology of psychiatric and medical comorbidity in neurodevelopmental disorders (NDDs) could improve patient diagnosis, stratification and treatment options. Rare tetratricopeptide repeat, ankyrin repeat and coiled-coil containing...
19.
Vidali S, Gerlini R, Thompson K, Urquhart J, Meisterknecht J, Aguilar-Pimentel J, et al.
EMBO Mol Med
. 2021 Nov;
13(12):e14397.
PMID: 34750991
Mitochondrial disorders are clinically and genetically diverse, with isolated complex III (CIII) deficiency being relatively rare. Here, we describe two affected cousins, presenting with recurrent episodes of severe lactic acidosis,...
20.
Clemen C, Schmidt A, Winter L, Canneva F, Wittig I, Becker L, et al.
Neuropathol Appl Neurobiol
. 2021 Jul;
48(1):e12750.
PMID: 34312900
Aims: We investigated N471D WASH complex subunit strumpellin (Washc5) knock-in and Washc5 knock-out mice as models for hereditary spastic paraplegia type 8 (SPG8). Methods: We generated heterozygous and homozygous N471D...