Logan Brase
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Explore the profile of Logan Brase including associated specialties, affiliations and a list of published articles.
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9
Citations
248
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Recent Articles
1.
Garg A, Vo S, Brase L, Aladyeva E, Albanus R, Nallapu A, et al.
Res Sq
. 2024 Nov;
PMID: 39483903
Background: Substantial evidence has established the critical role of microglia, the brain's resident immune cells, in the pathogenesis of Alzheimer's disease (AD). Microglia exhibit diverse transcriptional states in response to...
2.
Brase L, Yu Y, McDade E, Harari O, Benitez B
medRxiv
. 2024 May;
PMID: 38699303
Background: Single-cell technologies have unveiled various transcriptional states in different brain cell types. Transcription factors (TFs) regulate the expression of related gene sets, thereby controlling these diverse expression states. Apolipoprotein...
3.
Eteleeb A, Novotny B, Tarraga C, Sohn C, Dhungel E, Brase L, et al.
PLoS Biol
. 2024 Apr;
22(4):e3002607.
PMID: 38687811
Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning approaches to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical and...
4.
Sheehan P, Nadarajah C, Kanan M, Patterson J, Novotny B, Lawrence J, et al.
Neuron
. 2023 Jun;
111(15):2383-2398.e7.
PMID: 37315555
The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology are unknown. Here, we show that...
5.
Brase L, You S, DOliveira Albanus R, Del-Aguila J, Dai Y, Novotny B, et al.
Nat Commun
. 2023 Apr;
14(1):2314.
PMID: 37085492
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell-specific effect of variants in these genes...
6.
You S, Brase L, Filipello F, Iyer A, Del-Aguila J, He J, et al.
medRxiv
. 2023 Feb;
PMID: 36798226
Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the locus (rs1582763: protective and rs6591561:...
7.
Gratuze M, Schlachetzki J, DOliveira Albanus R, Jain N, Novotny B, Brase L, et al.
Neuron
. 2022 Nov;
111(2):202-219.e7.
PMID: 36368315
In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau-linked neurodegeneration and inflammation...
8.
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias F, Wall M, et al.
Nature
. 2021 Apr;
593(7858):255-260.
PMID: 33911285
Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no effective treatment for AD, passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) is a promising...
9.
Grover C, Pan M, Yuan D, Arick M, Hu G, Brase L, et al.
G3 (Bethesda)
. 2020 Mar;
10(5):1457-1467.
PMID: 32122962
Cotton is an important crop that has made significant gains in production over the last century. Emerging pests such as the reniform nematode have threatened cotton production. The rare African...