Bruno A Benitez
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Explore the profile of Bruno A Benitez including associated specialties, affiliations and a list of published articles.
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59
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3795
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Recent Articles
1.
Eteleeb A, Alves S, Buss S, Shafi M, Press D, Garcia-Cairasco N, et al.
medRxiv
. 2025 Feb;
PMID: 39974070
Background & Objective: Alzheimer's Disease (AD) patients at multiple stages of disease progression have a high prevalence of seizures. However, whether AD and epilepsy share pathophysiological changes remains poorly defined....
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Benitez B, Wallace C, Patel M, Nykanen N, Yuede C, Eaton S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605615
There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Alzheimer's disease (AD). Pathway analysis of post mortem brain-derived proteomic data from AD patients shows that...
4.
Das A, Erdman J, Heistand E, Lioutas V, Fehnel C, Yoon J, et al.
J Neurol Sci
. 2024 Nov;
467:123320.
PMID: 39591672
Objective: Acute hyperglycemia following intracerebral hemorrhage (ICH) is associated with poor functional outcomes and may result from a neuroendocrine stress response. Given the proximity of neuroendocrine structures to the cerebral...
5.
Brase L, Yu Y, McDade E, Harari O, Benitez B
medRxiv
. 2024 May;
PMID: 38699303
Background: Single-cell technologies have unveiled various transcriptional states in different brain cell types. Transcription factors (TFs) regulate the expression of related gene sets, thereby controlling these diverse expression states. Apolipoprotein...
6.
Eteleeb A, Novotny B, Tarraga C, Sohn C, Dhungel E, Brase L, et al.
PLoS Biol
. 2024 Apr;
22(4):e3002607.
PMID: 38687811
Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning approaches to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical and...
7.
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, et al.
medRxiv
. 2023 Jul;
PMID: 37461624
Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset...
8.
Sheehan P, Nadarajah C, Kanan M, Patterson J, Novotny B, Lawrence J, et al.
Neuron
. 2023 Jun;
111(15):2383-2398.e7.
PMID: 37315555
The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition in mice. However, the effects of BMAL1 on other aspects of neurodegenerative pathology are unknown. Here, we show that...
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Brase L, You S, DOliveira Albanus R, Del-Aguila J, Dai Y, Novotny B, et al.
Nat Commun
. 2023 Apr;
14(1):2314.
PMID: 37085492
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell-specific effect of variants in these genes...
10.
You S, Brase L, Filipello F, Iyer A, Del-Aguila J, He J, et al.
medRxiv
. 2023 Feb;
PMID: 36798226
Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the locus (rs1582763: protective and rs6591561:...