Loes E M Kistemaker
Overview
Explore the profile of Loes E M Kistemaker including associated specialties, affiliations and a list of published articles.
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27
Citations
628
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Recent Articles
1.
Rahmawati S, Vos R, Bos I, Kerstjens H, Kistemaker L, Gosens R
Sci Rep
. 2022 Jun;
12(1):11110.
PMID: 35773318
Asthmatics have elevated levels of IL-17A compared to healthy controls. IL-17A is likely to contribute to reduced corticosteroid sensitivity of human airway epithelium. Here, we aimed to investigate the mechanistic...
2.
Wu X, Ciminieri C, Bos I, Woest M, DAmbrosi A, Wardenaar R, et al.
Environ Pollut
. 2022 Apr;
305:119292.
PMID: 35439594
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by inflammation and impaired tissue regeneration, and is reported as the fourth leading cause of death worldwide by the...
3.
Wu X, Bos I, Conlon T, Ansari M, Verschut V, van der Koog L, et al.
Sci Adv
. 2022 Mar;
8(12):eabj9949.
PMID: 35319981
Currently, there is no pharmacological treatment targeting defective tissue repair in chronic disease. Here, we used a transcriptomics-guided drug target discovery strategy using gene signatures of smoking-associated chronic obstructive pulmonary...
4.
van den Berg M, Nijboer-Brinksma S, Bos I, van den Berge M, Lamb D, van Faassen M, et al.
Respir Res
. 2021 Feb;
22(1):48.
PMID: 33557843
Background: Asthma is a chronic respiratory disease in which the nervous system plays a central role. Sensory nerve activation, amongst others via Transient Receptor Potential Ankyrin 1 (TRPA1) channels, contributes...
5.
Wu X, Verschut V, Woest M, Ng-Blichfeldt J, Matias A, Villetti G, et al.
Front Pharmacol
. 2021 Feb;
11:609509.
PMID: 33551810
Transforming growth factor (TGF)-β-induced myofibroblast transformation and alterations in mesenchymal-epithelial interactions contribute to chronic lung diseases such as chronic obstructive pulmonary disease (COPD), asthma and pulmonary fibrosis. Rho-associated coiled-coil-forming protein...
6.
Dofferhoff A, Piscaer I, Schurgers L, Visser M, van den Ouweland J, de Jong P, et al.
Clin Infect Dis
. 2020 Aug;
73(11):e4039-e4046.
PMID: 32852539
Background: Respiratory failure and thromboembolism are frequent in severe acute respiratory syndrome coronavirus 2-infected patients. Vitamin K activates both hepatic coagulation factors and extrahepatic endothelial anticoagulant protein S, required for...
7.
Dragunas G, Woest M, Nijboer S, Bos S, van Asselt J, de Groot A, et al.
FASEB J
. 2020 Apr;
34(6):7703-7717.
PMID: 32277855
Parasympathetic neurons in the airways control bronchomotor tone. Increased activity of cholinergic neurons are mediators of airway hyperresponsiveness (AHR) in asthma, however, mechanisms are not elucidated. We describe remodeling of...
8.
Wu X, van Dijk E, Ng-Blichfeldt J, Bos I, Ciminieri C, Konigshoff M, et al.
Cells
. 2019 Sep;
8(10).
PMID: 31557955
Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, and is believed to be associated with accelerated ageing of the lung. Alveolar abnormalities leading to...
9.
Kistemaker L, Elzinga C, Tautermann C, Pieper M, Seeliger D, Alikhil S, et al.
Br J Pharmacol
. 2019 May;
176(16):2864-2876.
PMID: 31077341
Background And Purpose: The bronchodilator tiotropium binds not only to its main binding site on the M muscarinic receptor but also to an allosteric site. Here, we have investigated the...
10.
Wu X, van Dijk E, Bos I, Kistemaker L, Gosens R
Methods Mol Biol
. 2019 Feb;
1940:297-311.
PMID: 30788834
Precision-cut lung slices (PCLS) represent an ex vivo model widely used in visualizing interactions between lung structure and function. The major advantage of this technique is that the presence, differentiation...