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Machteld N Hylkema

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Articles 76
Citations 1432
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Recent Articles
1.
Pouwels S, Ter Haar E, Heijink I, Hylkema M, Koster T, Kuks P, et al.
Respiration . 2024 Sep; 103(12):765-776. PMID: 39348815
This meeting report provides an overview of the highlights of the Bronchitis XI international symposium, held in June 2024 in Groningen, The Netherlands. The theme of this year's symposium was...
2.
de Hilster R, Reinders-Luinge M, Schuil A, Borghuis T, Harmsen M, Burgess J, et al.
Bioengineering (Basel) . 2024 Sep; 11(9). PMID: 39329688
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by ongoing inflammation, impaired tissue repair, and aberrant interplay between airway epithelium and fibroblasts, resulting in an altered extracellular...
3.
Huo X, Xu X, Wang Q, Zhang J, Hylkema M, Zeng Z
Environ Int . 2024 Jun; 190:108833. PMID: 38908275
Background: Childhood exposure to polycyclic aromatic hydrocarbons (PAHs) or lead (Pb) is associated with epigenetic modifications. However, the effects of their co-exposures on IGF1 (Insulin-like growth factor 1) methylation and...
4.
Bartel S, Wolters J, Noor H, Rafie K, Fang J, Kirchner B, et al.
Cells . 2024 Jun; 13(11. PMID: 38891077
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease for which there is no cure. Accumulating research results suggest a role for extracellular vesicles (EVs) in the pathogenesis of...
5.
Zhang Z, Zhong Q, Qian Z, Zeng X, Zhang J, Xu X, et al.
J Hazard Mater . 2024 Jun; 475:134862. PMID: 38885585
The composition and metabolites of the gut microbiota can be altered by environmental pollutants. However, the effect of co-exposure to multiple pollutants on the human gut microbiota has not been...
6.
Zhang Z, Xu X, Qian Z, Zhong Q, Wang Q, Hylkema M, et al.
Environ Res . 2024 Jan; 247:118201. PMID: 38220074
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-quinone) has received extensive attention due to its ubiquitous distribution and potential toxicity. However, the distribution characteristics of 6PPD-quinone in dust from e-waste recycling areas and the consequential health...
7.
Wu D, Lau A, Xu Y, Reinders-Luinge M, Koncz M, Kiss A, et al.
Epigenetics . 2023 Nov; 18(1):2175522. PMID: 38016026
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers, but little is known about the molecular mechanism of UCHL1 in airway epithelium and its possible role in affecting extracellular...
8.
Migulina N, de Hilster R, Bartel S, Vedder R, van den Berge M, Nagelkerke A, et al.
Am J Physiol Cell Physiol . 2023 Nov; 326(1):C177-C193. PMID: 37955339
Fibroblasts are the main producers of extracellular matrix (ECM) responsible for ECM maintenance and repair, a process often disrupted in chronic lung diseases. The accompanying mechanical changes adversely affect resident...
9.
Faiz A, Mahbub R, Boedijono F, Tomassen M, Kooistra W, Timens W, et al.
Am J Respir Crit Care Med . 2023 Sep; 208(10):1075-1087. PMID: 37708400
IL-33 is a proinflammatory cytokine thought to play a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). A recent clinical trial using an anti-IL-33 antibody showed...
10.
Pfeiffer S, Jatzlauk G, Lund J, Boateng E, Kovacevic D, Hylkema M, et al.
Immun Inflamm Dis . 2022 Jul; 10(8):e675. PMID: 35894712
Early life exposures to antibiotics negatively impact respiratory health and are associated with an increased risk of childhood asthma. It is explained that the lung is inclined to develop chronic...