Lloyd D Fricker
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Explore the profile of Lloyd D Fricker including associated specialties, affiliations and a list of published articles.
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98
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2365
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Recent Articles
11.
Fricker L, Tashima A, Fakira A, Hochgeschwender U, Wetsel W, Devi L
Cell Chem Biol
. 2020 Nov;
28(1):105-112.e4.
PMID: 33217339
Neuropeptides and peptide hormones are important cell-cell signaling molecules that mediate many physiological processes. Unlike classic neurotransmitters, peptides undergo cell-type-specific post-translational modifications that affect their biological activity. To enable the...
12.
Fricker L, Margolis E, Gomes I, Devi L
Mol Pharmacol
. 2020 Jun;
98(2):96-108.
PMID: 32487735
In the mid-1970s, an intense race to identify endogenous substances that activated the same receptors as opiates resulted in the identification of the first endogenous opioid peptides. Since then, >20...
13.
Fricker L
Annu Rev Pharmacol Toxicol
. 2019 Sep;
60:457-476.
PMID: 31479618
Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into peptides. There are many distinct forms of proteasomes that differ in catalytically active subunits, regulatory subunits, and associated proteins....
14.
Fritz R, Mukherjee A, Zaghi S, Agalliu I, Jindal S, Tashima A, et al.
J Assist Reprod Genet
. 2019 Jul;
36(9):1891-1900.
PMID: 31346917
Purpose: Based on prior reports demonstrating that neutral endopeptidase (NEP) inhibitors increase sperm motility, the goal of our studies was to identify endogenous seminal peptides that inhibit NEP and investigate...
15.
Dasgupta S, Fishman M, Castro L, Tashima A, Ferro E, Fricker L
Biomolecules
. 2019 May;
9(6).
PMID: 31142026
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test...
16.
Fricker L
Adv Pharmacol
. 2018 Feb;
82:85-102.
PMID: 29413529
Peptides and small molecules that bind to peptide receptors are important classes of drugs that are used for a wide variety of different applications. The search for novel neuropeptides traditionally...
17.
Tashima A, Fricker L
J Am Soc Mass Spectrom
. 2017 Dec;
29(5):866-878.
PMID: 29235040
Quantitative peptidomics and proteomics often use chemical tags to covalently modify peptides with reagents that differ in the number of stable isotopes, allowing for quantitation of the relative peptide levels...
18.
Fricker L, Devi L
Pharmacol Ther
. 2017 Nov;
185:26-33.
PMID: 29174650
Neuropeptides are the largest class of intercellular signaling molecules, contributing to a wide variety of physiological processes. Neuropeptide receptors are therapeutic targets for a broad range of drugs, including medications...
19.
Garcia-Pardo J, Tanco S, Diaz L, Dasgupta S, Fernandez-Recio J, Lorenzo J, et al.
PLoS One
. 2017 Nov;
12(11):e0187778.
PMID: 29131831
Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways. Unlike other members of the metallocarboxypeptidase family, CPD...
20.
Berezniuk I, Rodriguiz R, Zee M, Marcus D, Pintar J, Morgan D, et al.
J Neurochem
. 2017 Sep;
143(3):268-281.
PMID: 28881029
To identify neuropeptides that are regulated by cocaine, we used a quantitative peptidomic technique to examine the relative levels of neuropeptides in several regions of mouse brain following daily intraperitoneal...