Lloyd D Fricker
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Explore the profile of Lloyd D Fricker including associated specialties, affiliations and a list of published articles.
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98
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2365
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Recent Articles
1.
Gomes I, Gupta A, Margolis E, Fricker L, Devi L
Mol Pharmacol
. 2024 Aug;
106(5):240-252.
PMID: 39187388
Ketamine is a glutamate receptor antagonist that was developed over 50 years ago as an anesthetic agent. At subanesthetic doses, ketamine and some metabolites are analgesics and fast-acting antidepressants, presumably...
2.
Schrader M, Fricker L
Methods Mol Biol
. 2024 Mar;
2758:485-498.
PMID: 38549031
The field of peptidomics has been under development since its start more than 20 years ago. In this chapter we provide a personal outlook for future directions in this field....
3.
Fricker L
Methods Mol Biol
. 2024 Mar;
2758:213-225.
PMID: 38549016
Peptidomic techniques are powerful tools to identify peptides in a biological sample. In the case of brain, which contains a complex mixture of cell types, standard peptidomics procedures reveal the...
4.
Tashima A, de Castro L, Fricker L
Methods Mol Biol
. 2024 Mar;
2758:109-124.
PMID: 38549011
A number of different approaches have been used for quantitative peptidomics. In this protocol, we describe the method in which peptides are reacted with formaldehyde and sodium cyanoborohydride, which converts...
5.
Fricker L
Methods Mol Biol
. 2024 Mar;
2758:89-108.
PMID: 38549010
Peptidomics is the detection and identification of the peptides present in a sample, and quantitative peptidomics provides additional information about the amounts of these peptides. It is possible to perform...
6.
Fridjonsdottir E, Nilsson A, Fricker L, Andren P
Methods Mol Biol
. 2024 Mar;
2758:49-60.
PMID: 38549007
Neuropeptides are bioactive peptides that are synthesized and secreted by neurons in signaling pathways in the brain. Peptides and proteins are extremely vulnerable to proteolytic cleavage when their biological surrounding...
7.
Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment
Aryal D, Rodriguiz R, Nguyen N, Pease M, Morgan D, Pintar J, et al.
Genes Brain Behav
. 2022 Jul;
21(7):e12827.
PMID: 35878875
ProSAAS is a neuroendocrine protein that is cleaved by neuropeptide-processing enzymes into more than a dozen products including the bigLEN and PEN peptides, which bind and activate the receptors GPR171...
8.
Fricker L, Duarte M, Jeltyi A, Lueptow L, Fakira A, Tashima A, et al.
Brain Res
. 2022 May;
1789:147951.
PMID: 35618016
Carboxypeptidase E (CPE) is an essential enzyme that contributes to the biosynthesis of the vast majority of neuropeptides and peptide hormones. There are several reports claiming that small decreases in...
9.
Lindberg I, Fricker L
Endocrinology
. 2021 Aug;
162(12).
PMID: 34333593
Peptides derived from proopiomelanocortin (POMC) are well-established neuropeptides and peptide hormones that perform multiple functions, including regulation of body weight. In humans and some animals, these peptides include α- and...
10.
Garcia-Pardo J, Tanco S, Garcia-Guerrero M, Dasgupta S, Aviles F, Lorenzo J, et al.
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33217972
Metallocarboxypeptidase Z (CPZ) is a secreted enzyme that is distinguished from all other members of the M14 metallocarboxypeptidase family by the presence of an N-terminal cysteine-rich Frizzled-like (Fz) domain that...