Lloyd C Trotman
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Explore the profile of Lloyd C Trotman including associated specialties, affiliations and a list of published articles.
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51
Citations
5123
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Recent Articles
1.
Wang H, Zhu C, Swamynathan M, Rajput S, Jayanetti K, Rendina D, et al.
Bioorg Med Chem
. 2025 Mar;
122:118136.
PMID: 40058274
Prostate cancer (PCa) is one of the most common malignancies diagnosed among men and is the second leading cause of cancer-related death. Despite recent advancements in early diagnosis of PCa,...
2.
Jun H, Paulo J, Appleman V, Yaron-Barir T, Johnson J, Yeo A, et al.
iScience
. 2024 Dec;
27(12):111278.
PMID: 39660053
PTEN plays a crucial role in preventing the development of glioblastoma (GBM), a severe and untreatable brain cancer. In GBM, most PTEN deficiencies are missense mutations that have not been...
3.
Swamynathan M, Kuang S, Watrud K, Doherty M, Gineste C, Mathew G, et al.
Science
. 2024 Oct;
386(6720):eadk9167.
PMID: 39446948
Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K...
4.
Amit M, Anastasaki C, Dantzer R, Demir I, Deneen B, Dixon K, et al.
Cancer Discov
. 2024 Apr;
14(4):669-673.
PMID: 38571430
The field of cancer neuroscience has begun to define the contributions of nerves to cancer initiation and progression; here, we highlight the future directions of basic and translational cancer neuroscience...
5.
Colucci M, Zumerle S, Bressan S, Gianfanti F, Troiani M, Valdata A, et al.
Cancer Cell
. 2024 Mar;
42(4):646-661.e9.
PMID: 38428412
Cellular senescence can exert dual effects in tumors, either suppressing or promoting tumor progression. The senescence-associated secretory phenotype (SASP), released by senescent cells, plays a crucial role in this dichotomy....
6.
Swamynathan M, Mathew G, Aziz A, Gordon C, Hillowe A, Wang H, et al.
Cancers (Basel)
. 2024 Jan;
16(1).
PMID: 38201488
Resistance to standard of care taxane and androgen deprivation therapy (ADT) causes the vast majority of prostate cancer (PC) deaths worldwide. We have developed RapidCaP, an autochthonous genetically engineered mouse...
7.
Hillowe A, Gordon C, Wang L, Rizzo R, Trotman L, Ojima I, et al.
PLoS One
. 2023 Oct;
18(10):e0292483.
PMID: 37796964
Prostate cancer is a leading cause of cancer-related deaths in men in the United States. Although treatable when detected early, prostate cancer commonly transitions to an aggressive castration-resistant metastatic state....
8.
Chung T, Garcia L, Swamynathan M, Froeling F, Trotman L, Tuveson D, et al.
Anal Chem
. 2023 Mar;
95(13):5661-5670.
PMID: 36952386
Imaging defined aspects of functional tumor biology with bioluminescent reporter transgenes is a popular approach in preclinical drug development as it is sensitive, relatively high-throughput and low cost. However, the...
9.
Taranda J, Mathew G, Watrud K, El-Amine N, Lee M, Elowsky C, et al.
Cell Rep
. 2021 Nov;
37(7):110027.
PMID: 34788609
Early steps of cancer initiation and metastasis, while critical for understanding disease mechanisms, are difficult to visualize and study. Here, we describe an approach to study the processes of initiation,...
10.
Lyons S, Plenker D, Trotman L
Cancer Drug Resist
. 2021 Sep;
4:745-754.
PMID: 34532655
The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer...