John E Wilkinson
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Explore the profile of John E Wilkinson including associated specialties, affiliations and a list of published articles.
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60
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3272
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Recent Articles
1.
Swamynathan M, Kuang S, Watrud K, Doherty M, Gineste C, Mathew G, et al.
Science
. 2024 Oct;
386(6720):eadk9167.
PMID: 39446948
Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K...
2.
Tsanov K, Barriga F, Ho Y, Alonso-Curbelo D, Livshits G, Koche R, et al.
bioRxiv
. 2024 Apr;
PMID: 38562717
Driver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations...
3.
Leibold J, Tsanov K, Amor C, Ho Y, Sanchez-Rivera F, Feucht J, et al.
Nat Cancer
. 2024 Jan;
5(2):315-329.
PMID: 38177458
Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of...
4.
Falvo D, Grimont A, Zumbo P, Fall W, Yang J, Osterhoudt A, et al.
Dev Cell
. 2023 Dec;
58(24):2959-2973.e7.
PMID: 38056453
Inflammation is essential to the disruption of tissue homeostasis and can destabilize the identity of lineage-committed epithelial cells. Here, we employ lineage-traced mouse models, single-cell transcriptomic and chromatin analyses, and...
5.
Wan L, Lin K, Rahman M, Ishigami Y, Wang Z, Jensen M, et al.
Cancer Discov
. 2023 Apr;
13(7):1678-1695.
PMID: 37098965
Significance: We describe the regulation of splicing factor SRSF1 expression in the context of pancreas cell identity, plasticity, and inflammation. SRSF1 protein downregulation is involved in a negative feedback cellular...
6.
Zhang Q, Yang L, Liu Y, Wilkinson J, Krainer A
Sci Transl Med
. 2023 Apr;
15(691):eadd8280.
PMID: 37043556
Diffuse midline gliomas (DMGs) are pediatric high-grade brain tumors in the thalamus, midbrain, or pons; the latter subgroup are termed diffuse intrinsic pontine gliomas (DIPG). The brain stem location of...
7.
Mou H, Eskiocak O, Ozler K, Gorman M, Yue J, Jin Y, et al.
J Pathol
. 2023 Jan;
259(4):415-427.
PMID: 36641763
CRISPR/Cas9-driven cancer modeling studies are based on the disruption of tumor suppressor genes by small insertions or deletions (indels) that lead to frame-shift mutations. In addition, CRISPR/Cas9 is widely used...
8.
Kim J, Wu C, Del Latto M, Gao Y, Choi S, Kierstead M, et al.
Cell Rep Methods
. 2023 Jan;
2(12):100353.
PMID: 36590695
We describe a mouse model of rectal cancer (RC) involving rapid tumor organoid engraftment via orthotopic transplantation in an immunocompetent setting. This approach uses simple mechanical disruption to allow engraftment,...
9.
Song D, Adrover J, Felice C, Christensen L, He X, Merrill J, et al.
JCI Insight
. 2022 Jul;
7(14).
PMID: 35866483
Acute lung injury (ALI) can cause acute respiratory distress syndrome (ARDS), a lethal condition with limited treatment options and currently a common global cause of death due to COVID-19. ARDS...
10.
He D, Feng H, Sundberg B, Yang J, Powers J, Christian A, et al.
Mol Cell
. 2022 Jun;
82(16):3045-3060.e11.
PMID: 35752173
Cancer mortality is primarily a consequence of its metastatic spread. Here, we report that methionine sulfoxide reductase A (MSRA), which can reduce oxidized methionine residues, acts as a suppressor of...