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Lise Pasquet

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Recent Articles
1.
Nishio K, Pasquet L, Camara K, DiSapio J, Hsu K, Kato S, et al.
J Clin Invest . 2023 Dec; 134(4). PMID: 38127463
In a structure-function study of sulfatides that typically stimulate type II NKT cells, we made an unexpected discovery. We compared analogs with sphingosine or phytosphingosine chains and 24-carbon acyl chains...
2.
Clark K, Yau J, Bloom A, Wang J, Venzon D, Suzuki M, et al.
Front Immunol . 2019 Oct; 10:2355. PMID: 31649670
iNKT cells are CD1d-restricted T cells recognizing lipid antigens. The prototypic iNKT cell-agonist α-galactosylceramide (α-GalCer) alongside compounds with similar structures induces robust proliferation and cytokine production of iNKT cells and...
3.
Bloom A, Bender L, Tiwary S, Pasquet L, Clark K, Jiang T, et al.
Oncoimmunology . 2019 Oct; 8(10):e1625687. PMID: 31646070
The benefits of anti-cancer agents extend beyond direct tumor killing. One aspect of cell death is the potential to release antigens that initiate adaptive immune responses. Here, a diffusion enhanced...
4.
Morales-Kastresana A, Musich T, Welsh J, Telford W, Demberg T, Wood J, et al.
J Extracell Vesicles . 2019 Jul; 8(1):1597603. PMID: 31258878
Biological nanoparticles, including viruses and extracellular vesicles (EVs), are of interest to many fields of medicine as biomarkers and mediators of or treatments for disease. However, exosomes and small viruses...
5.
Pasquet L, Bellard E, Chabot S, Markelc B, Rols M, Teissie J, et al.
J Immunother Cancer . 2019 Jun; 7(1):161. PMID: 31242938
Background: Melanoma is a very aggressive skin tumor that can be cured when diagnosed and treated in its early stages. However, at the time of identification, the tumor is frequently...
6.
Pasquet L, Chabot S, Bellard E, Rols M, Teissie J, Golzio M
Hum Gene Ther Methods . 2019 Jan; 30(1):17-22. PMID: 30632408
The skin is considered as well suited for gene therapy and vaccination. DNA vaccines elicit both broad humoral and cellular immune responses when injected in the skin. Physical and chemical...
7.
Pasquet L, Chabot S, Bellard E, Markelc B, Rols M, Reynes J, et al.
Sci Rep . 2018 Nov; 8(1):16833. PMID: 30443028
Gene transfer into cells or tissue by application of electric pulses (i.e. gene electrotransfer (GET)) is a non-viral gene delivery method that is becoming increasingly attractive for clinical applications. In...
8.
De Robertis M, Pasquet L, Loiacono L, Bellard E, Messina L, Vaccaro S, et al.
Cancers (Basel) . 2018 Oct; 10(11). PMID: 30373297
Cancer vaccines based on plasmid DNA represent a good therapeutic perspective, despite their low potency. Animal-derived hyaluronidases (Hyals) are employed in oncological clinical practice. Hyal has been also demonstrated to...
9.
OKonek J, Ambrosino E, Bloom A, Pasquet L, Massilamany C, Xia Z, et al.
Oncoimmunology . 2018 Jun; 7(7):e1439305. PMID: 29900040
A major advantage of immunotherapy of cancer is that effector cells induced at one site should be able to kill metastatic cancer cells in other sites or tissues. However, different...
10.
Paquin-Proulx D, Greenspun B, Pasquet L, Strunz B, Aleman S, Falconer K, et al.
Eur J Immunol . 2018 Apr; 48(8):1329-1335. PMID: 29677387
Innate lymphocytes are selectively enriched in the liver where they have important roles in liver immunology. Murine studies have shown that type I NKT cells can promote liver inflammation, whereas...