Douglas E Brough
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Explore the profile of Douglas E Brough including associated specialties, affiliations and a list of published articles.
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45
Citations
1023
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Recent Articles
1.
Norberg S, Valdez J, Napier S, Kenyon M, Ferraro E, Wheatley M, et al.
Lancet Respir Med
. 2025 Jan;
PMID: 39855244
Background: Recurrent respiratory papillomatosis (RRP) is a rare debilitating condition caused by chronic infection with human papillomavirus (HPV) type 6 or 11. Papillomas develop in the aerodigestive tract, leading to...
2.
Norberg S, Bai K, Sievers C, Robbins Y, Friedman J, Yang X, et al.
Sci Transl Med
. 2023 Oct;
15(719):eadj0740.
PMID: 37878675
Recurrent respiratory papillomatosis (RRP) is a rare, debilitating neoplastic disorder caused by chronic infection with human papillomavirus (HPV) type 6 or 11 and characterized by growth of papillomas in the...
3.
Osuna-Gomez R, Castellvi I, Mulet M, Ortiz M, Brough D, Sabzevari H, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445745
This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production. By comparing the cytokine levels in healthy donors...
4.
Osuna-Gomez R, Barril S, Mulet M, Zamora Atenza C, Millan-Billi P, Pardessus A, et al.
Immunology
. 2022 Oct;
168(4):610-621.
PMID: 36273280
Pulmonary fibrosis involves various types of immune cells and soluble mediators, including TGF-β and IL-35, a recently identified heterodimeric cytokine that belongs to the IL-12 cytokine family. However, the effect...
5.
St Peter M, Brough D, Lawrence A, Nelson-Brantley J, Huang P, Harre J, et al.
Front Bioeng Biotechnol
. 2022 Jun;
10:892969.
PMID: 35721868
Survival and integrity of the spiral ganglion is vital for hearing in background noise and for optimal functioning of cochlear implants. Numerous studies have demonstrated that supplementation of supraphysiologic levels...
6.
Lee M, Metenou S, Brough D, Sabzevari H, Bai K, Jochems C, et al.
NPJ Vaccines
. 2021 Jun;
6(1):86.
PMID: 34145272
Activation of antigen-specific T-lymphocyte responses may be needed to cure disorders caused by chronic infection with low-risk human papillomavirus (lrHPV). Safe and effective adjuvant therapies for such disorders are needed....
7.
Pellom S, Smalley Rumfield C, Morillon 2nd Y, Roller N, Poppe L, Brough D, et al.
JCI Insight
. 2021 Mar;
6(7).
PMID: 33651712
There are approximately 44,000 cases of human papillomavirus-associated (HPV-associated) cancer each year in the United States, most commonly caused by HPV types 16 and 18. Prophylactic vaccines successfully prevent healthy...
8.
Lu Z, Dmitriev I, Brough D, Kashentseva E, Li J, Curiel D
J Virol
. 2020 Feb;
94(10).
PMID: 32102889
Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in general populations worldwide has greatly limited their clinical utility....
9.
Pfannenstiel S, Praetorius M, Brough D, Staecker H
Anat Rec (Hoboken)
. 2020 Jan;
303(3):600-607.
PMID: 31916371
Factors influencing the damage to the inner ear can include the surgical approach used for vector delivery, the volume of vector used, the buffer that the vector is suspended in...
10.
Hassan A, Dmitriev I, Kashentseva E, Zhao H, Brough D, Fremont D, et al.
Cell Rep
. 2019 Sep;
28(10):2634-2646.e4.
PMID: 31484074
The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for...