Linford J B Briant
Overview
Explore the profile of Linford J B Briant including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
545
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Viloria K, Nasteska D, Ast J, Hasib A, Cuozzo F, Heising S, et al.
Diabetes
. 2022 Nov;
72(2):275-289.
PMID: 36445949
GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in the transport of circulating vitamin 25(OH)D and fatty acids, as well as actin scavenging. In the pancreatic islets,...
2.
Yang Y, Briant L, Raab C, Mullapudi S, Maischein H, Kawakami K, et al.
Elife
. 2022 Apr;
11.
PMID: 35373736
The importance of pancreatic endocrine cell activity modulation by autonomic innervation has been debated. To investigate this question, we established an in vivo imaging model that also allows chronic and...
3.
Dai X, Camunas-Soler J, Briant L, Dos Santos T, Spigelman A, Walker E, et al.
Cell Metab
. 2022 Feb;
34(2):256-268.e5.
PMID: 35108513
In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We examined α cells from human donors and...
4.
Miranda C, Begum M, Vergari E, Briant L
Peptides
. 2021 Nov;
147:170704.
PMID: 34826505
The pancreatic islets contain beta-cells and alpha-cells, which are responsible for secreting two principal gluco-regulatory hormones; insulin and glucagon, respectively. However, they also contain delta-cells, a relatively sparse cell type...
5.
Salem V, Delgadillo Silva L, Suba K, Georgiadou E, Mousavy Gharavy S, Akhtar N, et al.
Nat Metab
. 2020 Jul;
1(6):615-629.
PMID: 32694805
Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In the...
6.
Viloria K, Nasteska D, Briant L, Heising S, Larner D, Fine N, et al.
Cell Rep
. 2020 Jun;
31(11):107761.
PMID: 32553153
Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells....
7.
Kellard J, Rorsman N, Hill T, Armour S, van de Bunt M, Rorsman P, et al.
Mol Metab
. 2020 May;
40:101021.
PMID: 32446876
Objectives: Elevated plasma glucagon is an early symptom of diabetes, occurring in subjects with impaired glucose regulation. Here, we explored alpha-cell function in female mice fed a high-fat diet (HFD)....
8.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, et al.
Nat Metab
. 2020 Jan;
2(1):32-40.
PMID: 31993555
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting α-, insulin-producing β- and somatostatin-releasing δ-cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon...
9.
Vergari E, Knudsen J, Ramracheya R, Salehi A, Zhang Q, Adam J, et al.
Nat Commun
. 2019 Jan;
10(1):139.
PMID: 30635569
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of...
10.
Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, Gonzalez A, et al.
Physiol Rep
. 2018 Sep;
6(17):e13852.
PMID: 30187652
Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon-like peptide-1 (GLP-1) is released from the gut and...