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Lindy G Durrant

Explore the profile of Lindy G Durrant including associated specialties, affiliations and a list of published articles. Areas
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Articles 73
Citations 1729
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Recent Articles
1.
Al-Omari A, Cook K, Symonds P, Skinner A, Wright A, Zhu Y, et al.
NPJ Vaccines . 2024 Nov; 9(1):236. PMID: 39604380
Stresses within the tumour microenvironment can mediate post-translational modifications of self-proteins. Homocitrullination is the conversion of lysine to homocitrulline which generates neoepitopes and bypasses self-tolerance. In this study a vaccine...
2.
Pearson J, Puig-Saenz C, Thomas J, Hardowar L, Ahmad M, Wainwright L, et al.
Cancer Immunol Immunother . 2024 Jul; 73(9):178. PMID: 38954031
Intracranial tumors present a significant therapeutic challenge due to their physiological location. Immunotherapy presents an attractive method for targeting these intracranial tumors due to relatively low toxicity and tumor specificity....
3.
Sijmons D, Collett S, Soliman C, Guy A, Scott A, Durrant L, et al.
Sci Rep . 2024 Apr; 14(1):8587. PMID: 38615147
Helicobacter pylori infects approximately half the human population and has an unusual infective niche of the human stomach. Helicobacter pylori is a major cause of gastritis and has been classified...
4.
Shah S, Al-Omari A, Cook K, Paston S, Durrant L, Brentville V
Discov Immunol . 2024 Apr; 2(1):kyac011. PMID: 38567060
Complex cellular interactions between the immune system and cancer can impact tumour development, growth, and progression. T cells play a key role in these interactions; however, the challenge for T...
5.
Shah S, Cook K, Symonds P, Weisser J, Skinner A, Al Omari A, et al.
J Immunother Cancer . 2023 Oct; 11(10). PMID: 37857526
Background: Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in...
6.
Choudhury R, Daniels I, Vaghela P, Atabani S, Kirk T, Symonds P, et al.
Immunology . 2023 Apr; 169(4):467-486. PMID: 37055914
Citrullination and homocitrullination are stress induced post-translational modifications (siPTMs) which can be recognized by T cells. Peripheral blood mononuclear cells isolated from healthy donors and rheumatoid arthritis (RA) patients were...
7.
Houvast R, van Duijvenvoorde M, Chua J, Vankemmelbeke M, Durrant L, Inderson A, et al.
Mol Diagn Ther . 2023 Jan; 27(2):261-273. PMID: 36656512
Background: Targeted molecular imaging may improve tumor cell identification during diagnosis and resection of pancreatic ductal adenocarcinoma (PDAC). Although many molecular imaging biomarkers are (over)expressed in PDAC, intertumoral heterogeneity of...
8.
Brentville V, Symonds P, Chua J, Skinner A, Daniels I, Cook K, et al.
Front Immunol . 2022 Dec; 13:1066185. PMID: 36544781
Introduction: Post translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during...
9.
Michelakos T, Kontos F, Kurokawa T, Cai L, Sadagopan A, Krijgsman D, et al.
J Immunother Cancer . 2022 Mar; 10(3). PMID: 35277460
Purpose: The association of human leucocyte antigen (HLA) class I expression levels with the clinical course of many malignancies reflects their crucial role in the recognition and elimination of malignant...
10.
Choudhury R, Symonds P, Paston S, Daniels I, Cook K, Gijon M, et al.
J Immunother Cancer . 2022 Feb; 10(2). PMID: 35140112
Background: The enzymatic conversion of arginine to citrulline is involved in gene and protein regulation and in alerting the immune system to stressed cells, including tumor cells. Nucleophosmin (NPM) is...