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» Authors » Rachael L Metheringham

Rachael L Metheringham

Explore the profile of Rachael L Metheringham including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 238
Followers 0
Related Specialties
Allergy & Immunology
Oncology
Pharmacology
Top 10 Co-Authors
Lindy G Durrant
Victoria A Brentville
Peter Symonds
Katherine W Cook
Ian Daniels
Mohamed Gijon
Wei Xue
Barbara Gunn
Poonam Vaghela
Ruhul H Choudhury
Published In
J Immunother Cancer
Oncoimmunology
Eur J Immunol
Autophagy
Immunology
Affiliations
Soon will be listed here.
Recent Articles
1.
Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool
Choudhury R, Daniels I, Vaghela P, Atabani S, Kirk T, Symonds P, et al.
Immunology . 2023 Apr; 169(4):467-486. PMID: 37055914
Citrullination and homocitrullination are stress induced post-translational modifications (siPTMs) which can be recognized by T cells. Peripheral blood mononuclear cells isolated from healthy donors and rheumatoid arthritis (RA) patients were...
2.
PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy
Choudhury R, Symonds P, Paston S, Daniels I, Cook K, Gijon M, et al.
J Immunother Cancer . 2022 Feb; 10(2). PMID: 35140112
Background: The enzymatic conversion of arginine to citrulline is involved in gene and protein regulation and in alerting the immune system to stressed cells, including tumor cells. Nucleophosmin (NPM) is...
3.
Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses
Symonds P, Marcu A, Cook K, Metheringham R, Durrant L, Brentville V
Front Immunol . 2021 Dec; 12:764462. PMID: 34858415
Background: Somatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline. Citrullinated peptides...
4.
The Clinical and Prognostic Significance of Protein Arginine Deiminases 2 and 4 in Colorectal Cancer
Gijon M, Metheringham R, Toss M, Paston S, Durrant L
Pathobiology . 2021 Sep; 89(1):38-48. PMID: 34569542
Introduction: Protein arginine deiminases (PADIs) are a family of enzymes that catalyse the post-translational modification of proteins. Association between PADI expression and clinicopathology, protein expression, and outcome was determined. Methods:...
5.
Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy
Cook K, Xue W, Symonds P, Daniels I, Gijon M, Boocock D, et al.
J Immunother Cancer . 2021 Jul; 9(7). PMID: 34321274
Background: Homocitrullination is the post-translational modification of lysine that is recognized by T cells. Methods: This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used...
6.
Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses
Brentville V, Metheringham R, Daniels I, Atabani S, Symonds P, Cook K, et al.
J Immunother Cancer . 2020 Jun; 8(1). PMID: 32561639
Background: Stress-induced post-translational modifications occur during autophagy and can result in generation of new epitopes and immune recognition. One such modification is the conversion of arginine to citrulline by peptidylarginine...
7.
T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy
Brentville V, Symonds P, Cook K, Daniels I, Pitt T, Gijon M, et al.
Oncoimmunology . 2019 May; 8(5):e1576490. PMID: 31069134
Post-translational modifications are induced in stressed cells which cause them to be recognised by the system. One such modification is citrullination where the positive charged arginine is modified to a...
8.
Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial
Patel P, Ottensmeier C, Mulatero C, Lorigan P, Plummer R, Pandha H, et al.
Oncoimmunology . 2018 Jun; 7(6):e1433516. PMID: 29872563
A DNA vaccine, SCIB1, incorporating two CD8 and two CD4 epitopes from TRP-2/gp100 was evaluated in patients with metastatic melanoma. Each patient received SCIB1 via intramuscular injection with electroporation. The...
9.
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors
Xue W, Brentville V, Symonds P, Cook K, Yagita H, Metheringham R, et al.
Oncotarget . 2016 Nov; 7(50):83088-83100. PMID: 27825115
Purpose: We have previously shown that supraoptimal signaling of high avidity T cells leads to high expression of PD-1 and inhibition of proliferation. This study was designed to see if...
10.
SCIB2, an antibody DNA vaccine encoding NY-ESO-1 epitopes, induces potent antitumor immunity which is further enhanced by checkpoint blockade
Xue W, Metheringham R, Brentville V, Gunn B, Symonds P, Yagita H, et al.
Oncoimmunology . 2016 Jul; 5(6):e1169353. PMID: 27471648
Checkpoint blockade has demonstrated promising antitumor responses in approximately 10-40% of patients. However, the majority of patients do not make a productive immune response to their tumors and do not...