Lindy G Durrant
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Explore the profile of Lindy G Durrant including associated specialties, affiliations and a list of published articles.
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73
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1729
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Recent Articles
11.
Symonds P, Marcu A, Cook K, Metheringham R, Durrant L, Brentville V
Front Immunol
. 2021 Dec;
12:764462.
PMID: 34858415
Background: Somatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline. Citrullinated peptides...
12.
Houvast R, Thijse K, Groen J, Chua J, Vankemmelbeke M, Durrant L, et al.
Cancers (Basel)
. 2021 Nov;
13(22).
PMID: 34830932
Targeted molecular imaging may overcome current challenges in the preoperative and intraoperative delineation of pancreatic ductal adenocarcinoma (PDAC). Tumor-associated glycans Le, sdi-Le, sLe, sLe, sTn as well as mucin-1 (MUC1)...
13.
The Clinical and Prognostic Significance of Protein Arginine Deiminases 2 and 4 in Colorectal Cancer
Gijon M, Metheringham R, Toss M, Paston S, Durrant L
Pathobiology
. 2021 Sep;
89(1):38-48.
PMID: 34569542
Introduction: Protein arginine deiminases (PADIs) are a family of enzymes that catalyse the post-translational modification of proteins. Association between PADI expression and clinicopathology, protein expression, and outcome was determined. Methods:...
14.
Cook K, Xue W, Symonds P, Daniels I, Gijon M, Boocock D, et al.
J Immunother Cancer
. 2021 Jul;
9(7).
PMID: 34321274
Background: Homocitrullination is the post-translational modification of lysine that is recognized by T cells. Methods: This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used...
15.
Paston S, Brentville V, Symonds P, Durrant L
Front Immunol
. 2021 Apr;
12:627932.
PMID: 33859638
Vaccination was first pioneered in the 18th century by Edward Jenner and eventually led to the development of the smallpox vaccine and subsequently the eradication of smallpox. The impact of...
16.
Houvast R, Vankemmelbeke M, Durrant L, Wuhrer M, Baart V, Kuppen P, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33371487
Real-time tumor imaging techniques are increasingly used in oncological surgery, but still need to be supplemented with novel targeted tracers, providing specific tumor tissue detection based on intra-tumoral processes or...
17.
Pearson J, Cuzzubbo S, McArthur S, Durrant L, Adhikaree J, Tinsley C, et al.
Front Immunol
. 2020 Nov;
11:582106.
PMID: 33178210
Glioblastoma multiforme (GBM) is the most frequently occurring primary brain tumor and has a very poor prognosis, with only around 5% of patients surviving for a period of 5 years...
18.
Soliman C, Guy A, Chua J, Vankemmelbeke M, McIntosh R, Eastwood S, et al.
Biochem J
. 2020 Aug;
477(17):3219-3235.
PMID: 32789497
Immunotherapy has been successful in treating many tumour types. The development of additional tumour-antigen binding monoclonal antibodies (mAbs) will help expand the range of immunotherapeutic targets. Lewis histo-blood group and...
19.
Houvast R, Baart V, Bhairosingh S, Cordfunke R, Chua J, Vankemmelbeke M, et al.
Mol Imaging Biol
. 2020 Aug;
22(6):1511-1522.
PMID: 32780212
Purpose: Aberrantly expressed glycans in cancer are of particular interest for tumor targeting. This proof-of-concept in vivo study aims to validate the use of aberrant Lewis glycans as target for...
20.
Brentville V, Metheringham R, Daniels I, Atabani S, Symonds P, Cook K, et al.
J Immunother Cancer
. 2020 Jun;
8(1).
PMID: 32561639
Background: Stress-induced post-translational modifications occur during autophagy and can result in generation of new epitopes and immune recognition. One such modification is the conversion of arginine to citrulline by peptidylarginine...