Linda Irons
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Explore the profile of Linda Irons including associated specialties, affiliations and a list of published articles.
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10
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76
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Recent Articles
1.
Wang C, Irons L, Kimko H, Shah D
J Clin Pharmacol
. 2024 Nov;
PMID: 39539040
Antibody-drug conjugates (ADCs) have become a vital class of therapeutics in oncology because of their ability to selectively deliver potent drug molecules to tumor cells. However, ADC-associated toxicities cause high...
2.
Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Estrada A, Irons L, Tellides G, Humphrey J
J Biomech
. 2024 May;
169:112152.
PMID: 38763809
The healthy adult aorta is a remarkably resilient structure, able to resist relentless cardiac-induced and hemodynamic loads under normal conditions. Fundamental to such mechanical homeostasis is the mechano-sensitive cell signaling...
3.
Uatay A, Gall L, Irons L, Tewari S, Zhu X, Gibbs M, et al.
J Pharm Sci
. 2023 Oct;
113(1):11-21.
PMID: 37898164
Over the past several decades, mathematical modeling has been applied to increasingly wider scopes of questions in drug development. Accordingly, the range of modeling tools has also been evolving, as...
4.
Irons L, Cavinato C, Humphrey J
J Mech Behav Biomed Mater
. 2023 Jun;
144:105966.
PMID: 37327590
The healthy adult aorta exhibits a remarkable homeostatic ability to respond to sustained changes in hemodynamic loads under many circumstances, but this mechanical homeostasis can be compromised or lost in...
5.
Irons L, Estrada A, Humphrey J
Biomech Model Mechanobiol
. 2022 Jul;
21(5):1339-1355.
PMID: 35867282
Mature arteries exhibit a preferred biomechanical state in health evidenced by a narrow range of intramural and wall shear stresses. When stresses are perturbed by changes in blood pressure or...
6.
Estrada A, Irons L, Rego B, Li G, Tellides G, Humphrey J
PLoS Comput Biol
. 2021 Dec;
17(12):e1009683.
PMID: 34898595
Thoracic aortopathy-aneurysm, dissection, and rupture-is increasingly responsible for significant morbidity and mortality. Advances in medical genetics and imaging have improved diagnosis and thus enabled earlier prophylactic surgical intervention in many...
7.
Irons L, Latorre M, Humphrey J
Ann Biomed Eng
. 2021 Jan;
49(7):1701-1715.
PMID: 33415527
Tissue-level biomechanical properties and function derive from underlying cell signaling, which regulates mass deposition, organization, and removal. Here, we couple two existing modeling frameworks to capture associated multiscale interactions-one for...
8.
Irons L, Humphrey J
PLoS Comput Biol
. 2020 Aug;
16(8):e1008161.
PMID: 32834001
Arterial growth and remodeling at the tissue level is driven by mechanobiological processes at cellular and sub-cellular levels. Although it is widely accepted that cells seek to promote tissue homeostasis...
9.
Irons L, Huang H, Owen M, Odea R, Meininger G, Brook B
J Theor Biol
. 2020 Jul;
502:110387.
PMID: 32603668
Integrins regulate mechanotransduction between smooth muscle cells (SMCs) and the extracellular matrix (ECM). SMCs resident in the walls of airways or blood vessels are continuously exposed to dynamic mechanical forces...
10.
Irons L, Owen M, Odea R, Brook B
Biophys J
. 2018 Jun;
114(11):2679-2690.
PMID: 29874617
Integrin-mediated adhesions between airway smooth muscle (ASM) cells and the extracellular matrix (ECM) regulate how contractile forces generated within the cell are transmitted to its external environment. Environmental cues are...