Jay D Humphrey
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Explore the profile of Jay D Humphrey including associated specialties, affiliations and a list of published articles.
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197
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4789
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Recent Articles
1.
Daugherty A, Milewicz D, Dichek D, Ghaghada K, Humphrey J, LeMaire S, et al.
Arterioscler Thromb Vasc Biol
. 2025 Mar;
PMID: 40079138
There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induced by chemical...
2.
Ramachandra A, Sharma P, De Man R, Nikola F, Guerrera N, Doddaballapur P, et al.
bioRxiv
. 2025 Mar;
PMID: 40027757
Hypoxemia impairs cardiopulmonary function. We investigated pulmonary artery remodeling in mice exposed to chronic hypoxia for up to five weeks and quantified associated changes in cardiac and lung function, without...
3.
Jiang B, Ren P, He C, Wang M, Murtada S, Ruiz-Rodriguez M, et al.
JCI Insight
. 2025 Feb;
PMID: 39932797
Hypertension and transient increases in blood pressure from extreme exertion are risk factors for aortic dissection in patients with age-related vascular degeneration or inherited connective tissue disorders. Yet, a common...
4.
Estrada A, Humphrey J
Ann Biomed Eng
. 2025 Feb;
PMID: 39904866
Purpose: Multiple cell types interact within the aortic wall to control development, homeostasis, and adaptation as well as to drive disease progression. Given the complexity of these interactions and their...
5.
Holzapfel G, Humphrey J, Ogden R
J R Soc Interface
. 2025 Jan;
22(222):20240361.
PMID: 39876788
The human body consists of many different soft biological tissues that exhibit diverse microstructures and functions and experience diverse loading conditions. Yet, under many conditions, the mechanical behaviour of these...
6.
Rolf-Pissarczyk M, Schussnig R, Fries T, Fleischmann D, Elefteriades J, Humphrey J, et al.
Prog Mater Sci
. 2025 Jan;
150.
PMID: 39830801
Aortic dissection continues to be responsible for significant morbidity and mortality, although recent advances in medical data assimilation and in experimental and models have improved our understanding of the initiation...
7.
Pfaller M, Latorre M, Schwarz E, Gerosa F, Szafron J, Humphrey J, et al.
Comput Methods Appl Mech Eng
. 2024 Oct;
431.
PMID: 39430055
Equilibrated fluid-solid-growth (FSGe) is a fast, open source, three-dimensional (3D) computational platform for simulating interactions between instantaneous hemodynamics and long-term vessel wall adaptation through mechanobiologically equilibrated growth and remodeling (G&R)....
8.
Paukner D, Humphrey J, Cyron C
Biomech Model Mechanobiol
. 2024 Oct;
23(6):2115-2136.
PMID: 39419845
Constrained mixture models have successfully simulated many cases of growth and remodeling in soft biological tissues. So far, extensions of these models have been proposed to include either intracellular signaling...
9.
Middendorp E, Braeu F, Baaijens F, Humphrey J, Cyron C, Loerakker S
Biomech Model Mechanobiol
. 2024 Sep;
23(6):1889-1907.
PMID: 39269523
During the Ross procedure, an aortic heart valve is replaced by a patient's own pulmonary valve. The pulmonary autograft subsequently undergoes substantial growth and remodeling (G&R) due to its exposure...
10.
Cavinato C, Spronck B, Caulk A, Murtada S, Humphrey J
J R Soc Interface
. 2024 Aug;
21(217):20240110.
PMID: 39192727
The renin-angiotensin system plays a key role in regulating blood pressure, which has motivated many investigations of associated mouse models of hypertensive arterial remodelling. Such studies typically focus on histological...