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Lidia M Goncalves

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Articles 39
Citations 213
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Recent Articles
1.
Amaral R, Concha T, Vitor J, Almeida A, Calado C, Goncalves L
Pharmaceutics . 2025 Jan; 17(1). PMID: 39861778
: is the leading cause of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoma. Due to the emerging problems with antibiotic treatment against in clinical practice, vaccination has gained...
2.
Girst G, Lopes E, Goncalves L, Espadinha M, Kusz N, Wang H, et al.
RSC Med Chem . 2023 Sep; 14(9):1778-1786. PMID: 37731691
The combination of compounds with complementary bioactivities into hybrid molecules is an emerging concept in drug discovery. In this study, we aimed to synthesize new hybrid compounds based on p53-MDM2/X...
3.
Lamela-Gomez I, Goncalves L, Almeida A, Luzardo-Alvarez A
Drug Deliv Transl Res . 2023 Jun; 13(12):3030-3058. PMID: 37294425
Microencapsulation of the therapeutical monoclonal antibody infliximab (INF) was investigated as an innovative approach to improve its stability and to achieve formulations with convenient features for intra-articular administration. Ultrasonic atomization...
4.
Silva B, Goncalves L, Braz B, Delgado E
Pharmaceuticals (Basel) . 2023 Jun; 16(2). PMID: 37259314
The present work investigates the effects of chitosan-hyaluronic acid-epoetin beta (CS/HA-EPOβ) nanoparticles after topical ocular administration in a rat glaucoma model. Wistar Hannover rats ( = 24) were submitted to...
5.
Silva B, Goncalves L, Braz B, Delgado E
Sci Rep . 2023 Jan; 13(1):1559. PMID: 36707615
Topical instillation of drugs targeting the posterior ocular segment is an expanding area of research. Chitosan and hyaluronic acid have remarkable mucoadhesive properties and potentially enhance pre-corneal retention time after...
6.
Silva S, Marto J, Goncalves L, Duarte D, Soares O, Vasques-Novoa F, et al.
Int J Mol Sci . 2022 Jul; 23(13). PMID: 35806112
Nanoparticulate systems have been widely investigated as delivery vectors for efficient drug delivery in different diseases. Nanostructured lipid carriers (NLC) are composed of both solid and liquid lipids (glyceryl dibehenate...
7.
Bettencourt A, Goncalves L
Adv Exp Med Biol . 2022 May; 1357:19-41. PMID: 35583639
Different types of natural and synthetic polymeric nanocarriers are being tested for diverse biomedical applications ranging from drug/gene delivery vehicles to imaging probes. The development of such innovative nanoparticulate systems...
8.
Silva S, Marto J, Goncalves L, Fernandes H, Sousa S, Almeida A, et al.
Molecules . 2022 May; 27(9). PMID: 35566093
Functionalization of nanoparticles surfaces have been widely used to improve diagnostic and therapeutic biological outcome. Several methods can be applied to modify nanoparticle surface; however, in this article we focus...
9.
Silva B, Goncalves L, Braz B, Delgado E
Mar Drugs . 2022 Feb; 20(2). PMID: 35200680
Neuroprotection in glaucoma using epoetin beta (EPOβ) has yielded promising results. Our team has developed chitosan-hyaluronic acid nanoparticles (CS/HA) designed to carry EPOβ into the ocular globe, improving the drug's...
10.
Vieira A, Vital N, Rolo D, Roque R, Goncalves L, Bettencourt A, et al.
Food Chem Toxicol . 2022 Jan; 161:112841. PMID: 35093430
The widespread use of titanium dioxide nanomaterials (TiO NMs) in food and consumer products such as toothpaste or food contact materials, suggests the relevance of human oral exposure to these...