Liang-Chieh Chen
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Explore the profile of Liang-Chieh Chen including associated specialties, affiliations and a list of published articles.
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24
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1422
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Recent Articles
1.
Yang C, Li C, Sie Y, Chen L, Yuan Y, Hou W
Bot Stud
. 2024 Dec;
65(1):38.
PMID: 39692936
Background: Hispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked...
2.
Stephens E, Chen L, Ansari A, Shen K, Zhang L, Guillen S, et al.
ACS Med Chem Lett
. 2024 Nov;
15(11):1940-1946.
PMID: 39563804
Poly-ADP-ribose polymerases (PARPs) that catalyze cellular ADP-ribosylation play important roles in human health. PARP inhibitors have found success in the clinic for cancer treatment. However, isoform-specific inhibitors are needed for...
3.
Kim H, Hariri K, Zhang X, Chen L, Katz B, Pei H, et al.
Protein Sci
. 2024 Mar;
33(4):e4924.
PMID: 38501590
Targeted delivery of small-molecule drugs via covalent attachments to monoclonal antibodies has proved successful in clinic. For this purpose, full-length antibodies are mainly used as drug-carrying vehicles. Despite their flexible...
4.
Sie Y, Chen L, Li C, Wang C, Li C, Liu D, et al.
Antioxidants (Basel)
. 2023 Dec;
12(12).
PMID: 38136179
In this paper, the seeds and rinds of passion fruit, which are the agricultural waste of juice processing, were recycled to investigate their biological activities for sustainable use. De-oiled seed...
5.
Sie Y, Chen L, Li C, Yuan Y, Hsiao S, Lee M, et al.
Antioxidants (Basel)
. 2023 Jul;
12(7).
PMID: 37507902
Currently, no drug is effective in delaying the cognitive impairment of Alzheimer's disease, which ranks as one of the top 10 causes of death worldwide. Hydroxylated stilbenes are active compounds...
6.
Chu J, Tseng H, Lee S, Hsu K, Hsin L, Liang R, et al.
J Enzyme Inhib Med Chem
. 2023 May;
38(1):2212326.
PMID: 37190931
Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer's disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite...
7.
Yen S, Wu Y, Huang C, Chao M, Tu H, Chen L, et al.
Phytomedicine
. 2022 Apr;
100:154061.
PMID: 35364561
Background: Acute myeloid leukemia (AML) is a heterogeneous disease with poor overall survival characterized by various genetic changes. The continuous activation of oncogenic pathways leads to the development of drug...
8.
Yen S, Chen L, Huang H, HuangFu W, Chen Y, Lin T, et al.
Bioorg Chem
. 2022 Feb;
121:105675.
PMID: 35182882
Fms-like tyrosine kinase 3 (FLT3) is considered a promising therapeutic target for acute myeloid leukemia (AML) in the clinical. However, monotherapy with FLT3 inhibitor is usually accompanied by drug resistance....
9.
Wu Y, Chao M, Tu H, Chen L, Hsu K, Liou J, et al.
Oncogenesis
. 2021 May;
10(5):39.
PMID: 33986242
Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is commonly used for patient treatment. Drug-drug interaction is a major concern of combined therapy; hence, dual/multi-target inhibitors have become...
10.
Hsu J, Rao Sathyan A, Hsu K, Chen L, Yen C, Tseng H, et al.
J Nat Prod
. 2021 Feb;
84(4):1096-1103.
PMID: 33600175
Type 2 diabetes mellitus (T2DM) is associated with pancreatic β-cell dysfunction and insulin resistance. Islet amyloid polypeptide (IAPP) aggregation is found to induce islet β-cell death in T2DM patients. Recently,...