Tony Eight Lin
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Explore the profile of Tony Eight Lin including associated specialties, affiliations and a list of published articles.
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53
Citations
321
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Recent Articles
1.
Hsu J, Hsu K, Chou C, He T, Lin T, Sung T, et al.
Biomed Pharmacother
. 2025 Feb;
184:117891.
PMID: 39955852
Cyclin-dependent kinase 8 (CDK8) plays a crucial role in the transforming growth factor beta (TGF-β) signaling pathway, which is critical to the pathology of idiopathic pulmonary fibrosis (IPF). CDK8 promotes...
2.
Chou C, Huang W, Hsu K, Hsu J, Lin T, Yang C
Int J Biol Sci
. 2025 Jan;
21(2):685-707.
PMID: 39781457
Pulmonary fibrosis (PF) is a high-mortality lung disease with limited treatment options, highlighting the need for new therapies. Cyclin-dependent kinase 8 (CDK8) is a promising target due to its role...
3.
Lin T, Chou C, Wu Y, Sung T, Hsu J, Yen S, et al.
J Chem Inf Model
. 2024 Dec;
65(1):378-389.
PMID: 39740163
Pulmonary fibrosis is excessive scarring of the lung tissues. Transforming growth factor-beta (TGF-β) has been implicated in pulmonary fibrosis due to its ability to induce the epithelial-to-mesenchymal transition (EMT) and...
4.
Chen J, Tu H, Lin T, Peng Z, Wu Y, Yen S, et al.
Biomed Pharmacother
. 2024 Nov;
181:117688.
PMID: 39591664
The dual-specificity tyrosine-phosphorylation-regulated kinase 1 A (DYRK1A) presents a promising therapeutic target for neurological diseases. However, current inhibitors lack selectivity, which can lead to unexpected side effects and increase the...
5.
Shih W, Huang H, HuangFu W, Lin T, Sung T, Li M, et al.
Int J Biol Macromol
. 2024 Nov;
283(Pt 1):137296.
PMID: 39515714
Pancreatic ductal adenocarcinoma (PDAC) has limited treatment options, underscoring the urgent need for developing new therapies. The upregulation of TBK1 activity plays a crucial role in multiple pancreatic cancer-related signaling...
6.
Tu H, Chao M, Lee C, Peng C, Wu Y, Lin T, et al.
J Enzyme Inhib Med Chem
. 2024 Nov;
39(1):2418470.
PMID: 39494990
Dual-specificity tyrosine-regulated kinase 1 A (DYRK1A) is crucial in neurogenesis, synaptogenesis, and neuronal functions. Its dysregulation is linked to neurodegenerative disorders like Down syndrome and Alzheimer's disease. Although the development...
7.
Peng C, Hwang T, Hung S, Tu H, Tseng Y, Lin T, et al.
Int J Biol Macromol
. 2024 Oct;
282(Pt 4):136860.
PMID: 39481728
Alzheimer's disease (AD) is an irreversible neurodegenerative disease, with tau pathology caused by abnormally activated dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) being one of the culprits. Coumestrol, a phytoestrogen and natural...
8.
Hsu K, Huang Y, Chu J, Huang Y, Hu J, Lin T, et al.
J Enzyme Inhib Med Chem
. 2024 Sep;
39(1):2406025.
PMID: 39316378
Class IIa histone deacetylases (HDACs) have been linked to tumorigenesis in various cancers. Previously, we designed phenylhydroxamic acid as a potent class IIa HDAC inhibitor. However, it also unselectively inhibited...
9.
Tang D, Chen I, Chou P, Lai M, Liu Z, Tsai K, et al.
Eur J Med Chem
. 2024 Sep;
278:116801.
PMID: 39241481
The rational installation of pharmacophores targeting HSP90 and LSD1 axes has achieved significant anti-cancer capacity in prostate and colorectal cancer. Among the series of hybrids, inhibitor 6 exhibited remarkable anti-proliferative...
10.
Lin H, Tsai T, Hsu K, Hsu Y, Chiang L, El-Shazly M, et al.
Mar Drugs
. 2024 Jul;
22(7).
PMID: 39057432
Marine natural products offer immense potential for drug development, but the limited supply of marine organisms poses a significant challenge. Establishing aquaculture presents a sustainable solution for this challenge by...