Li-Yuan Chen
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Explore the profile of Li-Yuan Chen including associated specialties, affiliations and a list of published articles.
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55
Citations
752
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Recent Articles
1.
Yan H, Ding H, Xie R, Liu Z, Yang X, Xie L, et al.
Front Cardiovasc Med
. 2024 Oct;
11:1436764.
PMID: 39350967
Ischemic heart disease refers to the imbalance between the supply and demand of myocardial blood; it has various causes and results in a class of clinical diseases characterized by myocardial...
2.
Wang S, Awad K, Chen L, Siddique M, Ferreyra G, Wang C, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 Aug;
327(4):L503-L519.
PMID: 39159362
In hypoxic and pseudohypoxic rodent models of pulmonary hypertension (PH), hypoxia-inducible factor (HIF) inhibition attenuates disease initiation. However, HIF activation alone, due to genetic alterations or use of inhibitors of...
3.
Fruh S, Boudkkazi S, Koppensteiner P, Sereikaite V, Chen L, Fernandez-Fernandez D, et al.
Sci Adv
. 2024 Jul;
10(28):eadk5462.
PMID: 38985877
Adherens junction-associated protein 1 (AJAP1) has been implicated in brain diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely expressed in neurons and binds to γ-aminobutyric acid...
4.
Yin X, Chen X, Qiu J, Yu Z, Chen L, Huang S, et al.
Eur J Med Chem
. 2024 Mar;
268:116229.
PMID: 38430852
Betel-quid chewing addiction is the leading cause of oral submucous fibrosis and oral cancer, resulting in significant socio-economic burdens. Vaccination may serve as a promising potential remedy to mitigate the...
5.
Chen H, Chen H, Chen B, Lou S, Chen L, Lin C
Heliyon
. 2023 Jul;
9(8):e18472.
PMID: 37520946
Background: With age, people begin to experience deterioration in standing balance, especially when sensory input is suddenly removed or added. Here, we sought to explore the effects of age on...
6.
Dougherty E, Chen L, Awad K, Ferreyra G, Demirkale C, Keshavarz A, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Apr;
324(6):L783-L798.
PMID: 37039367
NR2F2 is expressed in endothelial cells (ECs) and knockout produces lethal cardiovascular defects. In humans, reduced expression is associated with cardiovascular diseases including congenital heart disease and atherosclerosis. Here, silencing...
7.
Avoli M, Chen L, Di Cristo G, Librizzi L, Scalmani P, Shiri Z, et al.
Neurobiol Dis
. 2023 Mar;
180:106097.
PMID: 36967064
We review here the neuronal mechanisms that cause seizures in focal epileptic disorders and, specifically, those involving limbic structures that are known to be implicated in human mesial temporal lobe...
8.
Brusca S, Elinoff J, Zou Y, Jang M, Kong H, Demirkale C, et al.
Circulation
. 2022 Aug;
146(14):1033-1045.
PMID: 36004627
Background: Cell-free DNA (cfDNA) is a noninvasive marker of cellular injury. Its significance in pulmonary arterial hypertension (PAH) is unknown. Methods: Plasma cfDNA was measured in 2 PAH cohorts (A,...
9.
Chen L, Tang R, Wu Y, Lai C, Chuang T
J Org Chem
. 2022 Apr;
87(9):5925-5937.
PMID: 35404617
Methylene and methyl tricyclic isoquinolinones were selectively prepared using a palladium(II)-catalyzed aerobic aza-Wacker reaction, followed by a base- and temperature-controlled Heck reaction catalyzed by palladium(0). Exo- to endo-double-bond migration in...
10.
Lu M, Chen L, Gairhe S, Mazer A, Anderson S, Nelson J, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Jan;
322(3):L315-L332.
PMID: 35043674
Treatment with mineralocorticoid receptor (MR) antagonists beginning at the outset of disease, or early thereafter, prevents pulmonary vascular remodeling in preclinical models of pulmonary arterial hypertension (PAH). However, the efficacy...