John Blenis
Overview
Explore the profile of John Blenis including associated specialties, affiliations and a list of published articles.
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Articles
153
Citations
18774
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Recent Articles
1.
Koundouros N, Nagiec M, Bullen N, Noch E, Burgos-Barragan G, Li Z, et al.
Science
. 2025 Mar;
387(6739):eadm9805.
PMID: 40080571
Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrient signaling...
2.
Shafer M, Low V, Li Z, Blenis J
Cell Metab
. 2025 Feb;
37(2):316-329.
PMID: 39908986
Propionate metabolism dysregulation has emerged as a source of metabolic health alterations linked to aging, cardiovascular and renal diseases, obesity and diabetes, and cancer. This is supported by several large...
3.
Csibi A, Lee G, Yoon S, Tong H, Ilter D, Elia I, et al.
Curr Biol
. 2024 Dec;
35(1):232.
PMID: 39675354
No abstract available.
4.
He L, Cho S, Blenis J
Genes Dev
. 2024 Nov;
39(1-2):109-131.
PMID: 39572234
The mechanistic target of rapamycin (mTOR) pathway senses and integrates various environmental and intracellular cues to regulate cell growth and proliferation. As a key conductor of the balance between anabolic...
5.
Ogawa T, Isik M, Wu Z, Kurmi K, Meng J, Cho S, et al.
Mol Cell
. 2024 Nov;
84(23):4558-4575.e8.
PMID: 39571580
Cellular growth and organismal development are remarkably complex processes that require the nutrient-responsive kinase mechanistic target of rapamycin complex 1 (mTORC1). Anticipating that important mTORC1 functions remained to be identified,...
6.
Hanif S, Au C, Torregroza I, Jannath S, Fabiha T, Bhinder B, et al.
bioRxiv
. 2024 Aug;
PMID: 39091857
G protein-coupled receptors (GPCRs) are the largest class of membrane-bound receptors and transmit critical signals from the extracellular to the intracellular spaces. Transcriptomic data of resected breast tumors shows that...
7.
Ferrarone J, Thomas J, Unni A, Zheng Y, Nagiec M, Gardner E, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2403685121.
PMID: 38743625
The tumor suppressor LKB1 is a serine/threonine protein kinase that is frequently mutated in human lung adenocarcinoma (LUAD). LKB1 regulates a complex signaling network that is known to control cell...
8.
Yaron-Barir T, Joughin B, Huntsman E, Kerelsky A, Cizin D, Cohen B, et al.
Nature
. 2024 May;
629(8014):1174-1181.
PMID: 38720073
Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth. Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that...
9.
Lau A, Blenis J, Burgos-Barragan G
Cancer Res
. 2024 Feb;
84(8):1191-1194.
PMID: 38364233
Serine metabolism plays a pivotal role in cancer, making it an appealing therapeutic target. Two recent studies published in Nature Metabolism and Science Translational Medicine uncovered novel players and therapeutic...
10.
Nagiec M, Blenis J
Curr Biol
. 2023 Dec;
33(24):R1289-R1291.
PMID: 38113839
Lysosomes are highly dynamic organelles that rapidly respond to changes in cellular nutrient status. A new study identifies a phosphoinositide switch that dictates lysosome function during nutrient starvation.