Leos Valasek
Overview
Explore the profile of Leos Valasek including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1047
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Recent Articles
1.
Pospisek M, Valasek L
Methods Enzymol
. 2013 Sep;
530:173-81.
PMID: 24034321
More than one 80S monosome can translate an mRNA molecule at a time producing polysomes. The most widely used method to separate 40S and 60S ribosomal subunits from 80S monosomes...
2.
Walker S, Zhou F, Mitchell S, Larson V, Valasek L, Hinnebusch A, et al.
RNA
. 2012 Dec;
19(2):191-207.
PMID: 23236192
Eukaryotic translation initiation factor (eIF)4B stimulates recruitment of mRNA to the 43S ribosomal pre-initiation complex (PIC). Yeast eIF4B (yeIF4B), shown previously to bind single-stranded (ss) RNA, consists of an N-terminal...
3.
Masek T, Valasek L, Pospisek M
Methods Mol Biol
. 2010 Dec;
703:293-309.
PMID: 21125498
Velocity separation of translation complexes in linear sucrose gradients is the ultimate method for both analysis of the overall fitness of protein synthesis as well as for detailed investigation of...
4.
Nemoto N, Singh C, Udagawa T, Wang S, Thorson E, Winter Z, et al.
J Biol Chem
. 2010 Aug;
285(42):32200-12.
PMID: 20699223
In eukaryotes, the 40 S ribosomal subunit serves as the platform of initiation factor assembly, to place itself precisely on the AUG start codon. Structural arrangement of the 18 S...
5.
Cuchalova L, Kouba T, Herrmannova A, Danyi I, Chiu W, Valasek L
Mol Cell Biol
. 2010 Aug;
30(19):4671-86.
PMID: 20679478
Recent reports have begun unraveling the details of various roles of individual eukaryotic translation initiation factor 3 (eIF3) subunits in translation initiation. Here we describe functional characterization of two essential...
6.
Chiu W, Wagner S, Herrmannova A, Burela L, Zhang F, Saini A, et al.
Mol Cell Biol
. 2010 Jun;
30(18):4415-34.
PMID: 20584985
The C-terminal domain (CTD) of the a/Tif32 subunit of budding yeast eukaryotic translation initiation factor 3 (eIF3) interacts with eIF3 subunits j/Hcr1 and b/Prt1 and can bind helices 16 to...
7.
Elantak L, Wagner S, Herrmannova A, Karaskova M, Rutkai E, Lukavsky P, et al.
J Mol Biol
. 2010 Jan;
396(4):1097-116.
PMID: 20060839
Despite recent progress in our understanding of the numerous functions of individual subunits of eukaryotic translation initiation factor (eIF) 3, little is known on the molecular level. Using NMR spectroscopy,...
8.
Grousl T, Ivanov P, Frydlova I, Vasicova P, Janda F, Vojtova J, et al.
J Cell Sci
. 2009 May;
122(Pt 12):2078-88.
PMID: 19470581
Environmental stresses inducing translation arrest are accompanied by the deposition of translational components into stress granules (SGs) serving as mRNA triage sites. It has recently been reported that, in Saccharomyces...
9.
Szamecz B, Rutkai E, Cuchalova L, Munzarova V, Herrmannova A, Nielsen K, et al.
Genes Dev
. 2008 Sep;
22(17):2414-25.
PMID: 18765792
Yeast initiation factor eIF3 (eukaryotic initiation factor 3) has been implicated in multiple steps of translation initiation. Previously, we showed that the N-terminal domain (NTD) of eIF3a interacts with the...
10.
Nielsen K, Valasek L
Methods Enzymol
. 2007 Oct;
431:15-32.
PMID: 17923228
Protein complexes play a critical role in virtually all cellular processes that have been studied to date. Comprehensive knowledge of the architecture of a protein complex of interest is, therefore,...