Leonard H Augenlicht
Overview
Explore the profile of Leonard H Augenlicht including associated specialties, affiliations and a list of published articles.
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79
Citations
2791
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Recent Articles
1.
Verhagen M, Joosten R, Schmitt M, Valimaki N, Sacchetti A, Rajamaki K, et al.
Nat Genet
. 2024 Jun;
56(7):1456-1467.
PMID: 38902475
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown to suppress intestinal stemness. Here, we used Paneth...
2.
Choi J, Augenlicht L
Exp Mol Med
. 2024 Feb;
56(3):495-500.
PMID: 38424189
The intestinal epithelium is the first line of defense and acts as an interface between the vast microbial world within the gastrointestinal tract and the body's internal milieu. The intestinal...
3.
Bedard G, Gilaj N, Peregrina K, Brew I, Tosti E, Shaffer K, et al.
J Biol Chem
. 2023 Nov;
300(1):105492.
PMID: 38000655
Homozygous 5'-methylthioadenosine phosphorylase (MTAP) deletions occur in approximately 15% of human cancers. Co-deletion of MTAP and methionine adenosyltransferase 2 alpha (MAT2a) induces a synthetic lethal phenotype involving protein arginine methyltransferase...
4.
Verhagen M, Joosten R, Schmitt M, Valimaki N, Sacchetti A, Rajamaki K, et al.
bioRxiv
. 2023 Oct;
PMID: 37873142
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, was shown to suppress intestinal stemness. Here, we employed Paneth cells...
5.
Nauman M, Varshney S, Choi J, Augenlicht L, Stanley P
Sci Rep
. 2023 Oct;
13(1):17473.
PMID: 37838775
Notch signaling determines cell fates in mouse intestine. Notch receptors contain multiple epidermal growth factor-like (EGF) repeats modified by O-glycans that regulate Notch signaling. Conditional deletion of protein O-fucosyltransferase 1...
6.
Choi J, Houston M, Wang R, Ye K, Li W, Zhang X, et al.
Aging Cell
. 2023 Mar;
22(5):e13802.
PMID: 36864750
The intestinal epithelium consists of cells derived from continuously cycling Lgr5 intestinal stem cells (Lgr5 ISCs) that mature developmentally in an ordered fashion as the cells progress along the crypt-luminal...
7.
Verhagen M, Joosten R, Schmitt M, Sacchetti A, Choi J, Valimaki N, et al.
Res Sq
. 2023 Jan;
PMID: 36711533
Paneth cells (PCs), responsible for the secretion of antimicrobial peptides in the small intestine and for niche support to crypt-base columnar stem cells (CBCs), have been shown to respond to...
8.
Firestone R, Feng M, Basu I, Peregrina K, Augenlicht L, Schramm V
Sci Rep
. 2021 Apr;
11(1):8844.
PMID: 33893330
A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5'-methylthioadenosine phosphorylase (MTAP). Methylthio-DADMe-Immucillin-A (MTDIA) is an orally available, transition state analogue inhibitor of MTAP. 5'-Methylthioadenosine...
9.
Li W, Houston M, Peregrina K, Ye K, Augenlicht L
Cell Stem Cell
. 2021 Apr;
28(4):779.
PMID: 33798423
No abstract available.
10.
Li W, Houston M, Peregrina K, Ye K, Augenlicht L
Cell Stem Cell
. 2020 Jul;
27(1):11-12.
PMID: 32619509
No abstract available.