John M Mariadason
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Explore the profile of John M Mariadason including associated specialties, affiliations and a list of published articles.
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Articles
110
Citations
4333
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Recent Articles
1.
Lau D, Collin J, Mariadason J
Biomedicines
. 2024 May;
12(5).
PMID: 38791079
Recent advances in the treatment of gastric cancer (GC) with chemotherapy, immunotherapy, anti-angiogenic therapy and targeted therapies have yielded some improvement in survival outcomes; however, metastatic GC remains a lethal...
2.
Nightingale R, Reehorst C, Vukelic N, Papadopoulos N, Liao Y, Guleria S, et al.
Dev Cell
. 2024 May;
59(15):1988-2004.e11.
PMID: 38781975
The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood. Utilizing a mouse model of Ehf...
3.
Jenkins L, Luk I, Chionh F, Tan T, Needham K, Ayton J, et al.
Cell Death Dis
. 2024 Mar;
15(3):183.
PMID: 38429301
Metastatic BRAF colorectal cancer (CRC) carries an extremely poor prognosis and is in urgent need of effective new treatments. While the BRAF inhibitor encorafenib in combination with the EGFR inhibitor...
4.
Tran S, Juliani J, Harris T, Evangelista M, Ratcliffe J, Ellis S, et al.
Commun Biol
. 2024 Feb;
7(1):209.
PMID: 38378743
Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intestinal...
5.
Yakou M, Ghilas S, Tran K, Liao Y, Afshar-Sterle S, Kumari A, et al.
Sci Immunol
. 2023 Oct;
8(88):eadf2163.
PMID: 37801516
Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey and play a critical role in maintaining the gastrointestinal epithelium. We show that cytotoxic molecules important for defense...
6.
Ng I, Luk I, Nightingale R, Reehorst C, Davalos-Salas M, Jenkins L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Oct;
325(6):G508-G517.
PMID: 37788331
High-fat (HF) diets (HFDs) and inflammation are risk factors for colon cancer; however, the underlying mechanisms remain to be fully elucidated. The transcriptional corepressor HDAC3 has recently emerged as a...
7.
Chueh A, Tse J, Dickinson M, Ioannidis P, Jenkins L, Togel L, et al.
Clin Cancer Res
. 2023 Sep;
29(18):3826.
PMID: 37712140
No abstract available.
8.
Serrano A, Weber T, Berthelet J, El-Saafin F, Gadipally S, Charafe-Jauffret E, et al.
Commun Biol
. 2023 Aug;
6(1):821.
PMID: 37550477
Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts...
9.
Harris T, Liao Y, Shi W, Evangelista M, Pal B, Puthalakath H, et al.
Cancer Med
. 2023 May;
12(12):13522-13537.
PMID: 37148543
Background: Monepantel is an anti-helminthic drug that also has anti-cancer properties. Despite several studies over the years, the molecular target of monepantel in mammalian cells is still unknown, and its...
10.
Esmaeilniakooshkghazi A, Pham E, George S, Ahrorov A, Villagomez F, Byington M, et al.
FASEB J
. 2023 Feb;
37(3):e22786.
PMID: 36786724
Adherens junctions (AJs) are a defining feature of all epithelial cells. They regulate epithelial tissue architecture and integrity, and their dysregulation is a key step in tumor metastasis. AJ remodeling...