Leonard Guarente
Overview
Explore the profile of Leonard Guarente including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
134
Citations
19888
Followers
0
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Recent Articles
1.
Holmes H, Valentin R, Jerneren F, de Jager Loots C, Refsum H, Smith A, et al.
Aging Cell
. 2024 Jun;
23(10):e14255.
PMID: 38937999
Elevated plasma total homocysteine (tHcy) is associated with the development of Alzheimer's disease and other forms of dementia. In this study, we report the relationship between tHcy and epigenetic age...
2.
Guarente L, Sinclair D, Kroemer G
Cell Metab
. 2024 Jan;
36(2):354-376.
PMID: 38181790
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine,...
3.
Dellinger R, Holmes H, Hu-Seliger T, Butt R, Harrison S, Mozaffarian D, et al.
Hepatology
. 2022 Sep;
78(3):863-877.
PMID: 36082508
Background And Aims: The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment...
4.
Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G
PLoS One
. 2021 Mar;
16(3):e0248926.
PMID: 33765019
[This corrects the article DOI: 10.1371/journal.pone.0034805.].
5.
Marinescu A, Chen J, Holmes H, Guarente L, Mendes O, Morris M, et al.
Int J Toxicol
. 2020 Jul;
39(4):307-320.
PMID: 32715855
Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 shown to preferentially elevate the nicotinamide adenine dinucleotide (NAD+) metabolome compared to other vitamin B3 forms (nicotinic acid and...
6.
Igarashi M, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T, et al.
Aging Cell
. 2019 Mar;
18(3):e12935.
PMID: 30917412
The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but...
7.
Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al.
Cell
. 2019 Feb;
176(4):944-945.
PMID: 30735637
No abstract available.
8.
de la Rubia J, Drehmer E, Platero J, Benlloch M, Caplliure-Llopis J, Villaron-Casales C, et al.
Amyotroph Lateral Scler Frontotemporal Degener
. 2019 Jan;
20(1-2):115-122.
PMID: 30668199
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There...
9.
Dellinger R, Santos S, Morris M, Evans M, Alminana D, Guarente L, et al.
NPJ Aging Mech Dis
. 2018 Aug;
4:8.
PMID: 30155270
[This corrects the article DOI: 10.1038/s41514-017-0016-9.].
10.