Leonard Guarente
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Explore the profile of Leonard Guarente including associated specialties, affiliations and a list of published articles.
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134
Citations
19888
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Recent Articles
11.
Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al.
Cell
. 2018 Mar;
173(1):74-89.e20.
PMID: 29570999
A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health....
12.
Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, et al.
Hepatology
. 2018 Feb;
68(2):496-514.
PMID: 29457836
Conclusion: The dysregulation of SIRT1-DEPTOR-mTORC1 signaling is a critical determinant of ALD pathology; targeting SIRT1 and DEPTOR and selectively inhibiting mTORC1-S6K1 signaling may have therapeutic potential for treating ALD in...
13.
Dellinger R, Santos S, Morris M, Evans M, Alminana D, Guarente L, et al.
NPJ Aging Mech Dis
. 2017 Nov;
3:17.
PMID: 29184669
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this...
14.
Zainabadi K, Liu C, Caldwell A, Guarente L
PLoS One
. 2017 Sep;
12(9):e0185236.
PMID: 28937996
Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show that pharmacological activation of SIRT1 protects in...
15.
Imai S, Guarente L
NPJ Aging Mech Dis
. 2017 Jul;
2:16017.
PMID: 28721271
The coupling of nicotinamide adenine dinucleotide (NAD) breakdown and protein deacylation is a unique feature of the family of proteins called 'sirtuins.' This intimate connection between NAD and sirtuins has...
16.
Wellman A, Metukuri M, Kazgan N, Xu X, Xu Q, Ren N, et al.
Gastroenterology
. 2017 May;
153(3):772-786.
PMID: 28552621
Background & Aims: Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells, commensal gut microorganisms, and immune cells. Disruption of this homeostasis is associated with disorders such as...
17.
Zainabadi K, Liu C, Guarente L
PLoS One
. 2017 May;
12(5):e0178520.
PMID: 28542607
Activation of SIRT1 has previously been shown to protect mice against osteoporosis through yet ill-defined mechanisms. In this study, we outline a role for SIRT1 as a positive regulator of...
18.
Satoh A, Imai S, Guarente L
Nat Rev Neurosci
. 2017 May;
18(6):362-374.
PMID: 28515492
In mammals, recent studies have demonstrated that the brain, the hypothalamus in particular, is a key bidirectional integrator of humoral and neural information from peripheral tissues, thus influencing ageing both...
19.
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis
Cha Y, Han M, Cha H, Zoldan J, Burkart A, Jung J, et al.
Nat Cell Biol
. 2017 Apr;
19(5):445-456.
PMID: 28436968
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the 'Warburg effect', which is also observed in primed human...
20.
Ondracek C, Frappier V, Ringel A, Wolberger C, Guarente L
Cell Rep
. 2017 Mar;
18(10):2310-2319.
PMID: 28273448
Sirtuin enzymes depend on NAD to catalyze protein deacetylation. Therefore, the lowering of NAD during aging leads to decreased sirtuin activity and may speed up aging processes in laboratory animals...