Leonard B Maggi Jr
Overview
Explore the profile of Leonard B Maggi Jr including associated specialties, affiliations and a list of published articles.
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28
Citations
2264
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Recent Articles
11.
Chang C, Curtis J, Maggi Jr L, Faubert B, Villarino A, OSullivan D, et al.
Cell
. 2013 Jun;
153(6):1239-51.
PMID: 23746840
A "switch" from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However,...
12.
13.
Winkeler C, Kladney R, Maggi Jr L, Weber J
PLoS One
. 2012 Aug;
7(7):e42005.
PMID: 22860046
Osteoclasts are terminally differentiated cells that attach to bone and secrete proteases to degrade the bone matrix. The primary protease responsible for the degradation of the organic component of the...
14.
Chu L, Su M, Maggi Jr L, Lu L, Mullins C, Crosby S, et al.
J Clin Invest
. 2012 Jul;
122(8):2793-806.
PMID: 22751105
The histone methyltransferase WHSC1 (also known as MMSET) is overexpressed in multiple myeloma (MM) as a result of the t(4;14) chromosomal translocation and in a broad variety of other cancers...
15.
Vanderwaal R, Maggi Jr L, Weber J, Hunt C, Roti J
Cancer Res
. 2009 Jul;
69(16):6454-62.
PMID: 19638589
Cellular survival from radiation-induced DNA damage requires access to sites of damage for the assembly of repair complexes and the subsequent repair, particularly the repair of DNA double strand breaks...
16.
Maggi Jr L, Kuchenruether M, Dadey D, Schwope R, Grisendi S, Townsend R, et al.
Mol Cell Biol
. 2008 Sep;
28(23):7050-65.
PMID: 18809582
Nucleophosmin (NPM) (B23) is an essential protein in mouse development and cell growth; however, it has been assigned numerous roles in very diverse cellular processes. Here, we present a unified...
17.
Apicelli A, Maggi Jr L, Hirbe A, Miceli A, Olanich M, Schulte-Winkeler C, et al.
Mol Cell Biol
. 2007 Dec;
28(3):1068-80.
PMID: 18070929
The nucleolus is the center of ribosome synthesis, with the nucleophosmin (NPM) and p19(ARF) proteins antagonizing one another to either promote or inhibit growth. However, basal NPM and ARF proteins...
18.
Saporita A, Maggi Jr L, Apicelli A, Weber J
Curr Med Chem
. 2007 Jul;
14(17):1815-27.
PMID: 17627519
One of the outstanding fundamental questions in cancer cell biology concerns how cells coordinate cellular growth (or macromolecular synthesis) with cell cycle progression and mitosis. Intuitively, rapidly dividing cells must...
19.
Pelletier C, Maggi Jr L, Brady S, Scheidenhelm D, Gutmann D, Weber J
Cancer Res
. 2007 Feb;
67(4):1609-17.
PMID: 17308101
Nucleophosmin (B23) is a nucleolar phosphoprotein that has been implicated in numerous cellular processes. In particular, nucleophosmin interacts with nucleolar components of newly synthesized ribosomes to promote ribosome nuclear export....
20.
Steer S, Moran J, Christmann B, Maggi Jr L, Corbett J
J Immunol
. 2006 Aug;
177(5):3413-20.
PMID: 16920983
In response to virus infection or treatment with dsRNA, macrophages express the inducible form of cyclooxygenase-2 (COX-2) and produce proinflammatory prostaglandins. Recently, we have shown that NF-kappaB is required for...