Leon O Murphy
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Explore the profile of Leon O Murphy including associated specialties, affiliations and a list of published articles.
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44
Citations
9989
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Recent Articles
1.
Schmuckli-Maurer J, Bindschedler A, Wacker R, Wurgler O, Rehmann R, Lehmberg T, et al.
Commun Biol
. 2024 Nov;
7(1):1554.
PMID: 39572689
Plasmodium, the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane...
2.
Li J, Moretti F, Hidvegi T, Sviben S, Fitzpatrick J, Sundaramoorthi H, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Feb;
17(6):1007-1024.
PMID: 38336172
Background & Aims: In the classic form of α1-antitrypsin deficiency (ATD), the misfolded α1-antitrypsin Z (ATZ) variant accumulates in the endoplasmic reticulum (ER) of liver cells. A gain-of-function proteotoxic mechanism...
3.
Bonazzi S, Gray A, Thomsen N, Biag J, Labbe-Giguere N, Keaney E, et al.
J Med Chem
. 2023 Jul;
66(13):9095-9119.
PMID: 37399505
The allosteric inhibitor of the mechanistic target of rapamycin (mTOR) everolimus reduces seizures in tuberous sclerosis complex (TSC) patients through partial inhibition of mTOR functions. Due to its limited brain...
4.
Murphy L, Ktistakis N
Autophagy
. 2023 May;
19(8):2171-2174.
PMID: 37255335
As a maturing field that continues to provide fundamental insights into cell physiology, autophagy is also beginning to attract considerable interest from the biotechnology/pharmaceutical sector. For this Editor's corner, I...
5.
Bedard M, Niet S, Bernard E, Babunovic G, Cheng T, Aylan B, et al.
J Clin Invest
. 2023 Feb;
133(6).
PMID: 36757797
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche....
6.
Goodwin J, Walkup 4th W, Hooper K, Li T, Kishi-Itakura C, Ng A, et al.
Sci Adv
. 2021 Oct;
7(40):eabj2485.
PMID: 34597140
Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress, yet the molecular details of their activation...
7.
Mizushima N, Murphy L
Trends Biochem Sci
. 2020 Aug;
45(12):1080-1093.
PMID: 32839099
Autophagy is a lysosome-dependent intracellular degradation system required for various physiological processes and can be dysregulated in human disease. To understand its biological significance and underlying mechanisms, measuring autophagic activity...
8.
Kobylarz M, Goodwin J, Kang Z, Annand J, Hevi S, OMahony E, et al.
PLoS One
. 2020 Aug;
15(8):e0235551.
PMID: 32833964
VPS34 is a key regulator of endomembrane dynamics and cargo trafficking, and is essential in cultured cell lines and in mice. To better characterize the role of VPS34 in cell...
9.
Bonazzi S, Goold C, Gray A, Thomsen N, Nunez J, Karki R, et al.
J Med Chem
. 2020 Jan;
63(3):1068-1083.
PMID: 31955578
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value...
10.
Baquero P, Dawson A, Mukhopadhyay A, Kuntz E, Mitchell R, Olivares O, et al.
Leukemia
. 2018 Sep;
33(4):981-994.
PMID: 30185934
In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs). In clinical studies hydroxychloroquine (HCQ), the only clinically...