Leon O Murphy
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Explore the profile of Leon O Murphy including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Moretti F, Bergman P, Dodgson S, Marcellin D, Claerr I, Goodwin J, et al.
EMBO Rep
. 2018 Aug;
19(9).
PMID: 30126924
Autophagy maintains cellular homeostasis by targeting damaged organelles, pathogens, or misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated by the formation of autophagosomes, which can selectively enclose...
12.
Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung Y, et al.
Nat Commun
. 2017 Nov;
8(1):1804.
PMID: 29180704
Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not...
13.
dHennezel E, Abubucker S, Murphy L, Cullen T
mSystems
. 2017 Nov;
2(6).
PMID: 29152585
Cohabitation of microbial communities with the host enables the formation of a symbiotic relationship that maintains homeostasis in the gut and beyond. One prevailing model suggests that this relationship relies...
14.
Goodwin J, Dowdle W, DeJesus R, Wang Z, Bergman P, Kobylarz M, et al.
Cell Rep
. 2017 Sep;
20(10):2341-2356.
PMID: 28877469
Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are...
15.
Wlodarska M, Luo C, Kolde R, dHennezel E, Annand J, Heim C, et al.
Cell Host Microbe
. 2017 Jul;
22(1):25-37.e6.
PMID: 28704649
Host factors in the intestine help select for bacteria that promote health. Certain commensals can utilize mucins as an energy source, thus promoting their colonization. However, health conditions such as...
16.
Galluzzi L, Baehrecke E, Ballabio A, Boya P, Bravo-San Pedro J, Cecconi F, et al.
EMBO J
. 2017 Jun;
36(13):1811-1836.
PMID: 28596378
Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy...
17.
DeJesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, et al.
Elife
. 2016 Jun;
5.
PMID: 27351204
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening...
18.
Mirzaa G, Campbell C, Solovieff N, Goold C, Jansen L, Menon S, et al.
JAMA Neurol
. 2016 May;
73(7):836-845.
PMID: 27159400
Importance: Focal cortical dysplasia (FCD), hemimegalencephaly, and megalencephaly constitute a spectrum of malformations of cortical development with shared neuropathologic features. These disorders are associated with significant childhood morbidity and mortality....
19.
Honda A, Harrington E, Cornella-Taracido I, Furet P, Knapp M, Glick M, et al.
ACS Med Chem Lett
. 2016 Jan;
7(1):72-6.
PMID: 26819669
Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components. Until recently the study of autophagy has been hampered by the lack of reliable pharmacological tools, but selective...
20.
Eng C, Wang Z, Tkach D, Toral-Barza L, Ugwonali S, Liu S, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
113(1):182-7.
PMID: 26677873
Macroautophagy is a key stress-response pathway that can suppress or promote tumorigenesis depending on the cellular context. Notably, Kirsten rat sarcoma (KRAS)-driven tumors have been reported to rely on macroautophagy...