Leon J De Windt
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Explore the profile of Leon J De Windt including associated specialties, affiliations and a list of published articles.
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123
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4377
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Recent Articles
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2.
Hegenbarth J, Lezzoche G, De Windt L, Stoll M
Front Mol Med
. 2024 Aug;
2:839338.
PMID: 39086967
The heart has been the center of numerous transcriptomic studies in the past decade. Even though our knowledge of the key organ in our cardiovascular system has significantly increased over...
3.
Mangraviti N, De Windt L
Front Mol Med
. 2024 Aug;
2:836418.
PMID: 39086960
Heart disease represents one of the main challenges in modern medicine with insufficient treatment options. Whole genome sequencing allowed for the discovery of several classes of non-coding RNA (ncRNA) and...
4.
Vilaca A, Jesus C, Lino M, Hayman D, Emanueli C, Terracciano C, et al.
Mol Ther Nucleic Acids
. 2024 Jul;
35(3):102233.
PMID: 38974998
The delivery of therapeutic long non-coding RNAs (lncRNA) to the heart by extracellular vesicles (EVs) is promising for heart repair. H19, a lncRNA acting as a major regulator of gene...
5.
Beslika E, Leite-Moreira A, De Windt L, da Costa Martins P
Cardiovasc Res
. 2024 Mar;
120(5):461-475.
PMID: 38428029
Pathologic cardiac hypertrophy is a common consequence of many cardiovascular diseases, including aortic stenosis (AS). AS is known to increase the pressure load of the left ventricle, causing a compensative...
6.
Spano G, Pehlivanoglu S, De Windt L
Cardiovasc Res
. 2024 Jan;
120(1):10-12.
PMID: 38190721
No abstract available.
7.
Rabussier G, Bunter I, Bouwhuis J, Soragni C, van Zijp T, Ng C, et al.
Acta Biomater
. 2023 Apr;
164:363-376.
PMID: 37116636
Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the leading causes of maternal and perinatal morbidity in the world. Its fundamental mechanisms are yet poorly understood due to...
8.
Juni R, Kocken J, Abreu R, Ottaviani L, Davalan T, Duygu B, et al.
Mol Ther
. 2023 Apr;
31(6):1807-1828.
PMID: 37073128
While it is experimentally supported that impaired myocardial vascularization contributes to a mismatch between myocardial oxygen demand and supply, a mechanistic basis for disruption of coordinated tissue growth and angiogenesis...
9.
Soragni C, Vergroesen T, Hettema N, Rabussier G, Lanz H, Trietsch S, et al.
STAR Protoc
. 2023 Mar;
4(1):102051.
PMID: 36861838
Traditionally, to quantify permeability of a biological barrier, the initial slope is used, based on the assumption of sink condition (concentration of the donor is constant, and the receiver increases...
10.
de Boer M, Te Lintel Hekkert M, Chang J, van Thiel B, Martens L, Bos M, et al.
Aging Cell
. 2023 Feb;
22(3):e13768.
PMID: 36756698
Heart failure has reached epidemic proportions in a progressively ageing population. The molecular mechanisms underlying heart failure remain elusive, but evidence indicates that DNA damage is enhanced in failing hearts....