Meriem Bourajjaj
Overview
Explore the profile of Meriem Bourajjaj including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
646
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0
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Recent Articles
1.
Discovery of Targets for Immune-Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Sahu A, Wang X, Munson P, Klomp J, Wang X, Gu S, et al.
Cancer Discov
. 2023 Feb;
13(3):672-701.
PMID: 36745048
Significance: BipotentR presents resources for evaluating patient response and identifying targets for drugs that can kill tumors through multiple mechanisms concurrently. Inhibition of the topmost candidate target killed tumors by...
2.
Damanafshan A, Elzenaar I, Samson-Couterie B, van der Made I, Bourajjaj M, van den Hoogenhof M, et al.
Cardiovasc Res
. 2018 Apr;
114(11):1474-1486.
PMID: 29648621
Aims: The pathology of heart failure is characterized by poorly contracting and dilated ventricles. At the cellular level, this is associated with lengthening of individual cardiomyocytes and loss of sarcomeres....
3.
Wennink J, Liu Y, Makinen P, Setaro F, de la Escosura A, Bourajjaj M, et al.
Eur J Pharm Sci
. 2017 Jul;
107:112-125.
PMID: 28679107
Selective elimination of macrophages by photodynamic therapy (PDT) is a new and promising therapeutic modality for the reduction of atherosclerotic plaques. m-Tetra(hydroxyphenyl)chlorin (mTHPC, or Temoporfin) may be suitable as photosensitizer...
4.
Rad-Malekshahi M, Fransen M, Krawczyk M, Mansourian M, Bourajjaj M, Chen J, et al.
Mol Pharm
. 2017 Jan;
14(5):1482-1493.
PMID: 28088862
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines using novel nanocarriers based on self-assembling materials. Several studies demonstrated that peptide antigens in nanoparticulate...
5.
Strong in vivo antitumor responses induced by an antigen immobilized in nanogels via reducible bonds
Li D, Sun F, Bourajjaj M, Chen Y, Pieters E, Chen J, et al.
Nanoscale
. 2016 Oct;
8(47):19592-19604.
PMID: 27748778
Cancer vaccines are at present mostly based on tumor associated protein antigens but fail to elicit strong cell-mediated immunity in their free form. For protein-based vaccines, the main challenges to...
6.
Babae N, Bourajjaj M, Liu Y, van Beijnum J, Cerisoli F, Scaria P, et al.
Oncotarget
. 2014 Aug;
5(16):6687-700.
PMID: 25149532
Tumor-angiogenesis is the multi-factorial process of sprouting of endothelial cells (EC) into micro-vessels to provide tumor cells with nutrients and oxygen. To explore miRNAs as therapeutic angiogenesis-inhibitors, we performed a...
7.
Yousefi A, Bourajjaj M, Babae N, van Noort P, Schaapveld R, van Beijnum J, et al.
Int J Pharm
. 2014 Jun;
472(1-2):175-84.
PMID: 24950365
Angiogenesis is one of the hallmarks of cancer which renders it an attractive target for therapy of malignancies. Tumor growth suppression can be achieved by inhibiting angiogenesis since it would...
8.
Dirkx E, Gladka M, Philippen L, Armand A, Kinet V, Leptidis S, et al.
Nat Cell Biol
. 2013 Oct;
15(11):1282-93.
PMID: 24161931
Although aberrant reactivation of embryonic gene programs is intricately linked to pathological heart disease, the transcription factors driving these gene programs remain ill-defined. Here we report that increased calcineurin/Nfat signalling...
9.
Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, et al.
Cell Metab
. 2013 Sep;
18(3):341-54.
PMID: 24011070
Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy metabolism in the heart. Here, we propose a mechanism that integrates two deleterious characteristics of heart failure, hypoxia and...
10.
Azzouzi H, Leptidis S, Bourajjaj M, Van Bilsen M, da Costa Martins P, De Windt L
PLoS One
. 2012 Jun;
7(6):e36799.
PMID: 22723831
Background: The response of the postnatal heart to growth and stress stimuli includes activation of a network of signal transduction cascades, including the stress activated protein kinases such as p38...